Résumé
Hemoglobin Q-India (α 64 Asp→His) is an important member of the hemoglobin Q family, molecularly characterized by the replacement of aspartic acid by histidine. The first case of Hb Q India was reported by Sukumaran in 1972 in a Sindhi family with associated β-halassemia. India is known as a country with a high prevalence of α - and β-thalassemia and different types of hemoglobinopathy. Many of these variants are yet to be identified. Here, we are reporting two cases of Hb Q- India diagnosed during premarital thalassemia screening.
Résumé
Hemoglobin has plenty of variants and fast moving hemoglobins (FMH’s) are the rare hemoglobin variants. They are having tendency to migrate anodally to hemoglobin A on alkaline gel electrophoresis. Because of the mutation in the globin genes, these hemoglobin variants have the fast moving nature. The basic pathophysiology behind it is the substitution of a negatively charged amino acid residue in either α, β or γ globin chains. Hb J Meerut is an infrequently found α-globin variant. It has previously been reported in various populations around the world. Here, we are reporting a case of Hb J meerut who came to laboratory for thalassemia screening.