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1.
Article | IMSEAR | ID: sea-227905

RÉSUMÉ

The utilization of cannabis in oncology presents a multifaceted approach to addressing the complex challenges associated with cancer treatment. With roots tracing back to ancient medicinal practices, cannabis contains numerous compounds, including cannabinoids like tetrahydrocannabinol (THC) and cannabidiol (CBD), that interact with the body's endocannabinoid system. These interactions offer potential therapeutic benefits, ranging from antiemetic and analgesic effects to the inhibition of cancer growth processes. While clinical evidence supports the efficacy of cannabinoids in managing symptoms and enhancing the quality of life for cancer patients, caution is warranted due to potential interactions with conventional medications. Understanding the mechanisms of action, optimal administration routes, and potential side effects is crucial for integrating cannabis into personalized cancer care plans. By navigating these considerations thoughtfully, medical practitioners can harness the therapeutic potential of cannabis to complement traditional cancer treatments and improve patient outcomes in the field of oncology.

2.
Article | IMSEAR | ID: sea-219724

RÉSUMÉ

Background:Patients with xerostomia complain of not only dryness of mouth but also discomfort during routine normal oral functions like speaking and swallowing. These complainis worse in individuals wearing removable intraoral dental prosthesis. In such situations, when salivary flow decreases, denture adhesives and salivary substitutes are recommended; which aid in denture retention and improve patient comfort.Material & Method:A total 150 samples were prepared using heat-cure acrylic resin of 30mm×30mm×5mm. All samples were equally divided in A,B,C,D,E groups,wherein Group A was control group with salivary substitutes.Group B was denture adhesive cream without salivary substitutes.Group C was denture adhesive cream with salivary substitutes.Group D was denture adhesive strips without salivary substitutes.Group E was denture adhesive strips with salivary substitutes.The retentive force was measured for all samples usinguniversal testing machine.Results:Data was collected and statistical analysis was done by one-way ANOVA test followed by post hoc test. The significant difference was found between the retentive forces of cream type and strip type denture adhesives withor without salivary substitutes.Conclusion:From this study, it is concluded that denture adhesive will definitely increases the denture retention. The cream type denture adhesive with salivary substitutes has the most retention than among all groups.

3.
Indian J Pediatr ; 2006 Oct; 73(10): 885-8
Article de Anglais | IMSEAR | ID: sea-81410

RÉSUMÉ

OBJECTIVE: To analyze the frequency of del22q11.2 in non-syndromic CHDs using classical cytogenetics and Fluorescence In Situ Hybridization (FISH) technique in Indian population. METHODS: 105 prospective cases which included 6 families with isolated, non-syndromic cardiac defects were analyzed clinically by a cardiologist and a geneticist. The cases were then subjected to karyotypic (classical cytogenetics) as well as FISH analysis. The efficacy of FISH technique was compared with inference drawn from classical cytogenetics. RESULTS: Karyotypic analysis of all the 105 patients revealed a normal chromosomal complement. Microdeletion 22q11.2 was observed in six patients (5.71%) by FISH studies. FISH studies were also performed on the parents of these six patients who revealed a normal chromosome 22. No correlation was found between clinical features (mild or unspecific) with 22q11.2 microdeletion. CONCLUSION: The testing for microdeletion 22q11.2 in isolated non-syndromic patients using FISH technique is mandatory even when mild/unspecific extracardiac abnormalities are seen in the patients.


Sujet(s)
Adolescent , Adulte , Enfant , Enfant d'âge préscolaire , Délétion de segment de chromosome , Chromosomes humains de la paire 22 , Cardiopathies congénitales/génétique , Humains , Hybridation fluorescente in situ , Nourrisson , Nouveau-né , Caryotypage
4.
Indian J Pediatr ; 2005 Jun; 72(6): 489-91
Article de Anglais | IMSEAR | ID: sea-81465

RÉSUMÉ

OBJECTIVE: To study the overall frequency of congenital malformations in a city hospital in the first three days of life. METHODS: 17,653 consecutive newborns were examined and diagnosed at a maternity hospital by pediatricians and geneticists. Relevant information was documented on a predesigned proforma and analyzed. RESULTS: Of the 17,653 births 294 (1; 6%) had major malformations and 1400 (7.92%) had minor malformations. Amongst 17,653 births 328 (1.8%) were stillbirths. Malformations were highest in this group. Polygenic traits accounted for 45.1% while chromosomal etiology was found in 4%. A genetic basis was found in 65.4% of cases. CONCLUSION: With emphasis on ''small family '' norms & population control it is necessary to identify malformations so that Interventional programmes can be planned.


Sujet(s)
Malformations/épidémiologie , Humains , Nouveau-né , Surveillance de la population , Études prospectives
5.
Indian J Pediatr ; 2004 Nov; 71(11): 1042
Article de Anglais | IMSEAR | ID: sea-84287

RÉSUMÉ

Non-mosaic Trisomy 22 is the second most common autosomal trisomy found in spontaneous abortions but relatively uncommon in live births. We report a case of non mosaic trisomy 22 surviving till late infancy. The unique phenotype was microcephaly, large eyes with anti mongoloid slants, mild hypertelorism, broad depressed nasal bridge, large prominent bulbous nasal tip anteverted nostrils, long philtrum, small mouth with down turned corners, microretrognathia cleft palate and preauricular tags. Systemic examination showed a ventricular septal defect. The probands karyotype was 47, XX, der(15)t (15;22) (p12;q13),+der(22)mat. This karyotype is as the result of 3:1 interchange segregation in the mother who is a carrier of a balanced translocation. The proband had inherited two derivative chromosomes and extra chromosome from the mother besides one 22 from the father. This is known as interchange trisomy. We report the first such case from India discussing the possible reason for the late survivor of this usually lethal anomaly.

6.
Article de Anglais | IMSEAR | ID: sea-89952

RÉSUMÉ

OBJECTIVE: To determine dietary protein intake in Indian patients with chronic renal failure and the impact of prescribing protein restricted diets to these patients. METHODS: Baseline dietary protein intake was estimated in forty five patients with chronic renal failure on an unrestricted diet. Of these 45 patients, 27 were vegetarian and 18 were non-vegetarian. Then the patients were divided into 2 comparable groups. Twenty group I patients were allowed to continue unrestricted diet while 25 group II patients were advised 0.6 g/kg/day (50% high biological value) protein. Protein intake was estimated at 1 and 2 month follow up. RESULTS: The baseline dietary protein intake in 45 patients was 0.65 +/- 0.15 (mean +/- 1 SD) g/kg/day. There was no significant difference in protein intake of group I and group II patients at 1 and 2 month follow up. Also, the protein intake in group II patients was not different at 1 and 2 month follow up compared to baseline value. CONCLUSION: Protein intake of Indian patients with CRF is usually low even on an unrestricted diet. The usual practice of advising dietary protein restriction has no significant impact on the protein intake.


Sujet(s)
Adulte , Sujet âgé , Régime pauvre en protéines/méthodes , Femelle , Études de suivi , Humains , Inde , Défaillance rénale chronique/diagnostic , Mâle , Adulte d'âge moyen , Valeurs de référence , Résultat thérapeutique
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