Hypolipidemic and antioxidant activity of ethanolic extract of Symplocos racemosa Roxb. in hyperlipidemic rats: An evidence of participation of oxidative stress in hyperlipidemia.

Hypolipidemic and antioxidant activity profiles of ethanolic extracts of Symplocos racemosa (EESR) were studied by triton-WR1339 (acute) and high fat diet induced (chronic) hyperlipidemic rat models. In both the models, a significant increase in total cholesterol (TC), triglycerides (TG), very low density lipoproteins (VLDL), low density lipoproteins (LDL) and decrease in high density lipoproteins (HDL) in serum were observed. EESR (200 and 400 mg/kg) and simvastatin (10 mg/kg) administered orally reduced the elevated serum lipids (TC, TG, VLDL, LDL), restored the decreased HDL and improved the atherogenic index. In high fat diet induced hyperlipidemic model, EESR treatment prevented the increased formation of malondialdehyde (MDA) in liver, restored the depleted liver antioxidants, glutathione, superoxide dismutase, catalase significantly. The increased liver cholesterol, HMG-CoA reductase activity and body weight of hyperlipidemic rats were significantly reduced by EESR treatment. The EESR inhibited HMG-CoA reductase, a rate limiting enzyme in cholesterol biosynthesis, thereby causing hypolipidemic effects. EESR treatment also improved histoarchitecture of hepatocytes in hyperlipidemic rats. Experimental findings demonstrated anti-hyperlipidemic and antioxidant activity of EESR, which may be directly or indirectly related to its antioxidant activity. The hypolipidemic activity of EESR may be due to the presence of flavonoids phenolic compounds, phenolic glycosides and steroids.

Operational feasibility of establishing community reporting systems.

BACKGROUND: In developing countries the absence ofa credible disease surveillance system results in an inappropriate response to an outbreak. Since a functioning and responsive disease surveillance system cannot be provided immediately, some interim surveillance system for early detection of outbreaks is needed to institute a prompt response. This operational research study was conducted to assess the feasibility of establishing community reporting systems involving women self-help groups and members of Panchayati raj institutions through syndromic surveillance at the community level. METHODS: Reporting was initiated from 8 villages in 4 gram panchayats of Begunia block of Khurda district in Orissa during May and June 2005. Members of women self-help groups and Panchayati raj institutions were trained on structured reporting guidelines. In congruence with the state disease surveillance system, weekly reporting was started for comparison where feasible. RESULTS: Completeness of reporting was better achieved by women self-help groups (91.6%) than members of Panchayati raj institutions (66.6%). Data capture was more complete as compared with the existing disease surveillance system. Illnesses among women were better captured and greater ownership of the public health service was noted. CONCLUSION: Establishing community reporting systems using women self-help groups and members of Panchayat raj institutions for disease surveillance in India is a feasible option.

Idiopathic extensive spontaneous venous thrombosis (a case report).

Two patients with extensive spontaneous venous thrombosis are reported. Both had documented evidence of polyserositis, transient abnormalities of liver function tests along with normal coagulograms. Although one patient had a short, self-limiting illness, the other required treatment with coumarin derivatives. The relevant literature is discussed.