Molecular p prediction, docking studies and synthesis of 5-benzimidazole-1-Yl-methyl –[1,3,4] oxadiazole-2-thiol and their derivatives.

Molecular property is a complex balance of various structural features which determine whether a particular molecule is similar to the known drugs.These properties mainly hydrophobicity, molecular size,flexibility and presence of various pharmacophoric features influence the behavior of molecules in a living organism, including oral bioavailability. This investigation deals with the design and calculation of molecular properties, drug likeness, lipophilicity and solubility parameters of 5-Benzimidazole-1-yl-methyl-[1, 3, 4] oxadiazole-2-thiol and their derivatives using Osiris, mol inspiration ,Mol soft software’s, and ALOPGPS 2.1 program. The compounds followed the Lipinski ‘Rule of five’ for better bioavailability, were synthesized and characterized by IR, NMR, and mass spectral analysis. Furthermore, the binding conformations of these compounds for anti inflammatory activities were determined in silico docking. This is an energy optimization process concerned with the search of the lowest free energy binding mode of a ligand within a protein binding site and estimates the forces involved in the protein-ligand recognition, carried out in Mastro V 2011 in the active site of the cyclooxygenase-2 (COX-2) enzyme.

Bacterial endocarditis due to Eikenella corrodens: a case report.

Of all the causes of bacterial endocarditis, HACEK group consisting of Haemophilus, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella Kingae are rare causative agents. We report a case of bacterial endocarditis by E. corrodens, which is one of the members of the HACEK group.

Epidemic of Vibrio cholerae serogroup O139 in Berhampur, Orissa.

During the months of May-June 2000, 194 patients with watery diarrhoea were admitted to the Infectious Diseases Ward of the M.K.C.G. Medical College, Berhampur. Ninety four rectal swabs were collected and processed according to the standard procedures. Vibrio cholerae strains were isolated from 20 samples. Of these 20 isolates, two were found to be V. cholerae O1 EITor Ogawa strain and 18 were confirmed to be V. cholerae serotype O139. All V. cholerae O139 isolates were of a single phage type (phage type 1) and the two O1 strains were of phage type 3 and phage type 27 respectively. All 20 V. cholerae isolates were positive for CAMP test, and showed uniform resistance to furazolidone and sensitivity to co-trimoxazole, amoxycillin, norfloxacin, tetracycline and gentamycin. V. cholerae O139 serotype has not been reported earlier in south Orissa. This is probably the first report of its isolation from this area.

Rhinosporidiosis presenting as urethral polyp.

Rhinosporidiosis is a very common disease endemic in India, Ceylon, East Africa and part of America. Extremely rare in Europe. Nose, naso-pharynx, nasal sinuses, larynx are the common sites of affection, but urethral lesion is very rare. Reports from India so far as our knowledge goes are not available. Symmers may be the only case report available so far. For the rarity of site of affection, the case is reported.

Construction of growth reference standards for urban slum children in developing countries.

A cross-sectional sample of 2987 children in the age group of 1 to 10 years were selected from urban slums of Delhi for measurement of weight and height. Males and females were 53 and 47% respectively. Mean weight and height were calculated for both the sexes. Comparison of percentiles of weight and height with NCHS and ICMR standards showed that the 75th percentiles weight and height of the present study were comparable with 80 and 90% of 50th percentile of NCHS respectively. Hence, upper 25% of the sample arranged in ascending order of magnitude were used for the construction of reference standards of weight and height. Comparison of percentiles drawn from the top 25% of the sample demonstrated that 50th percentile of the present study corresponded to 80% of 50th percentile of the NCHS for weight and 90% of 50th percentile of NCHS of the height for both boys and girls. Also the 50th percentile of ICMR for weight and height for both the sexes. Standards constructed from such sample would be better suited for two important uses: (i) monitoring of Nutrition Programme, and (ii) to detect a child with abnormal growth at the earliest.