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1.
Indian J Pathol Microbiol ; 2012 Oct-Dec 55(4): 528-530
Article Dans Anglais | IMSEAR | ID: sea-145653

Résumé

WHO defines hepatocellular adenoma (HCA) as a benign tumor composed of cells closely resembling normal hepatocytes, which are arranged in plates separated by sinusoids. It is more common in women. The present concerns a 41 years female who was found to have a mass lesion in liver on ultrasound while undergoing routine evaluation for dyspepsia. Computed tomography scan of abdomen showed 10 × 8 cm lesion in liver. Extended left hepatectomy was performed. Grossly hepatic cut surface showed circumscribed tumor with dark gray or black color. Microscopy revealed hepatocellular adenoma with abundant Dubin Johnson like pigment deposition. CD34 immunostaining showed complete sinusoidal pattern. We labeled the tumor as pigmented hepatic adenoma with complete CD34 staining pattern. To the best of author's knowledge only eight cases of pigmented hepatocellular adenoma are described in world literature.

2.
Indian J Pathol Microbiol ; 2012 Oct-Dec 55(4): 506-508
Article Dans Anglais | IMSEAR | ID: sea-145646

Résumé

Mycophenolate mofetil (MMF) is a commonly used immunosuppressive drug in the management of transplant recipients. Gastrointestinal (GI) toxicity (diarrhea) is the most frequently reported adverse event in MMF-treated transplant patients. MMF-induced Graft versus Host Disease has rarely been reported in literature. We report a case of MMF-induced colitis with Graft versus Host Disease-like features, to highlight the importance of high clinical suspicion for its diagnosis, and that appropriate management in such a setting can reduce morbidity and mortality. We also review the relevant literature.

3.
Indian J Pathol Microbiol ; 2012 Apr-Jun 55(2): 236-238
Article Dans Anglais | IMSEAR | ID: sea-142231

Résumé

Solitary fibrous tumor (SFT) of the liver is an extremely rare neoplasm of mesenchymal origin. In the English literature, less than 40 cases of SFTs of the liver have been reported. The present case concerns a 34-year-old female who presented to us with complaint of dyspepsia. On examination, there was hepatomegaly. On ultrasound examination, an SOL in the liver was detected. Large tumor measuring 14.5 × 10 × 8 cm was resected. Microscopic evaluation of the tumor showed a well-circumscribed, low to moderately cellular tumor demonstrating spindle- and fibroblast-like cells within the collagenous stroma. Immunohistochemistry revealed diffuse strong cytoplasmic immunopositivity of CD34, Bcl2, and vimentin. A diagnosis of a benign SFT was given. The patient remained well 4 years after surgery. SFT is a rare mesenchymal neoplasm that occasionally involves the liver in adult patients. Most SFTs are benign, but some may have malignant histological features. With less than 40 reported cases in the literature, little can be said regarding its natural history or the benefits of adjuvant radio chemotherapy. Complete surgical resection remains the cornerstone of its treatment.


Sujets)
Adulte , Antigènes CD34/analyse , Femelle , Histocytochimie , Humains , Immunohistochimie , Tumeurs du foie/diagnostic , Tumeurs du foie/anatomopathologie , Tumeurs du foie/chirurgie , Tumeurs du foie/imagerie diagnostique , Microscopie , Protéines proto-oncogènes c-bcl-2/analyse , Tumeurs fibreuses solitaires/diagnostic , Tumeurs fibreuses solitaires/anatomopathologie , Tumeurs fibreuses solitaires/chirurgie , Résultat thérapeutique , États-Unis , Vimentine/analyse
4.
Indian J Pathol Microbiol ; 2009 Jan-Mar; 52(1): 34-7
Article Dans Anglais | IMSEAR | ID: sea-73988

Résumé

OBJECTIVE: To study cervical smear abnormalities in urban women in India and women in Mauritius and to compare the results in the two groups. STUDY DESIGN: An analysis of 6010 cervical smears taken as part of routine check-ups in an urban hospital was done and an analysis of 10,000 cervical smears taken from women participating in a National Cancer Screening Program in Mauritius was done. Emphasis was put on cervical epithelial cell abnormalities and the results in the two populations are compared with that of similar studies in other parts of the world. RESULTS: Non specific inflammation formed 19.6% and 25.34% of the smears in the Indian and Mauritian groups, respectively (with specific infection forming 6.05% and 15.08%). The epithelial abnormalities constituted 1.392% of the Indian group and 0.47% of the Mauritian group. The difference was statistically significant in the atypical squamous cells of uncertain significance (ASCUS) and atypical glandular cells of uncertain significance (AGUS) group. CONCLUSIONS: The prevalence of low-grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL) is similar to that in the developed world.


Sujets)
Adolescent , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Femelle , Hôpitaux urbains , Humains , Inde/épidémiologie , Dépistage de masse/méthodes , Maurice/épidémiologie , Adulte d'âge moyen , Tumeurs épidermoïdes/épidémiologie , Prévalence , Indice de gravité de la maladie , Tumeurs du col de l'utérus/épidémiologie , Frottis vaginaux , Vaginite/épidémiologie , Jeune adulte
5.
Article Dans Anglais | IMSEAR | ID: sea-65042

Résumé

Hepatobiliary and vascular manifestations are rare form of extraintestinal manifestations in Crohn's disease. We report a 20-year-old man in whom cerebral venous sinus thrombosis was the presenting symptom and preceded the diagnosis of Crohn's disease.


Sujets)
Adulte , Anticoagulants/administration et posologie , Maladie de Crohn/diagnostic , Diagnostic différentiel , Association de médicaments , Études de suivi , Humains , Thrombose intracrânienne/diagnostic , Angiographie par résonance magnétique , Mâle , Phénytoïne/administration et posologie , Appréciation des risques , Indice de gravité de la maladie , Tomodensitométrie , Résultat thérapeutique
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