Résumé
Objective To observe the value of conventional ultrasound combined with ultrasonic elastography for evaluating the severity of active lesions of juvenile localized scleroderma(JLS).Methods Totally 27 JLS children with 46 active lesions were prospectively enrolled.The thickness,echo and blood flow of skin and subcutaneous tissue of JLS lesions and the paired sites were evaluated using conventional ultrasound,while the skin stiffness of all lesions and paired sites were assessed using shear wave elastography(SWE),and the strain ratio of lesions and surrounding skin were evaluated using strain elastography(SE).The thickness,echo and blood flow of skin as well as subcutaneous tissue,and the Young's modulus of skin were compared between JLS active lesions and the paired sites.The correlations of the individual sum total of each Young's modulus and the limited scleroderma activity index(LoSAI)or the limited scleroderma injury index(LoSDI)were explored.Results Compared with the paired site,no significant difference of the skin thickness was found among 46 JLS lesions(P＞0.05),but JLS lesions had thinner subcutaneous tissue(P＜0.05)and greater Young's moduli(all P＜0.05).The strain ratio of the lesions and surrounding skin were all larger than 2.For JLS children with active lesions,the individual sum total of Young's moduli had moderate rank correlations with LoSAI(rs=0.63-0.69,all P＜0.05),but there was no significant rank correlation with LoSDI(rs=0.27-0.33,P＞0.05).Conclusion Compared with the paired site,JLS active lesions had thinner subcutaneous tissue and stiffer skin.The higher the lesion skin stiffness,the more severe the JLS lesion activity.
Résumé
Objective To investigate the prevalence of and influencing factors for atopic dermatitis (AD)in children aged 1-7 years in Shenzhen city,and to analyze difference in diagnostic results between two diagnostic criteria.Methods From December 1st 2013 to March 1st 2014,a questionnaire survey and physical examination were conducted to investigate the prevalence of AD in children aged 1-7 years in Shenzhen city.Results A total of 1 504 children were enrolled into this study,including 716 males and 788 females.Based on the clinical diagnosis by experienced dermatologists,the prevalence of AD was 11.84％ (17811 504) in total,11.73％ (84/716) and 11.93％ (94/788) in males and females,respectively,and there was no significant difference in the prevalence of AD between males and females (x2 =0.01,P ＞0.05).Based on the Williams' diagnostic criteria,the prevalence of AD was 3.92％ (59/1 504) in total,and 4.05％ (29/716) and 3.81％ (30/788) in males and females,respectively.Premature birth was a risk factor for the occurrence of AD (x2 =5.43,P ＜ 0.05).Conclusions The prevalence of AD is evidently increased among children aged 1-7 years in Shenzhen city,and premature birth is a risk factor for AD.Missed diagnosis will be reduced based on clinical diagnosis by experienced dermatologists.