Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtre
Ajouter des filtres








Gamme d'année
1.
Biol. Res ; 46(1): 75-78, 2013. ilus, tab
Article Dans Anglais | LILACS | ID: lil-676824

Résumé

Curare, a selective skeletal muscle relaxant, has been used clinically to reduce shivering and as an anesthetic auxiliary in abdominal surgery. It is also widely used in animal experiments to block neuromuscular junction activity. Effective doses of curare diminish muscle contraction without affecting brain function, but at higher doses it is known to be lethal. However, the exact dose of curare initiating muscle relaxation vs. lethal effect has not been fully characterized in mice. In this study we carefully examined the dose-response for achieving muscle inactivity over lethality in both male and female mice (C57BL6/J). The most striking finding of this study is that female mice were highly susceptible to curare; both the EDm and LDm were at least 3-fold lower than male littermates. This study shows that gender-specific differences can be an important factor when administering skeletal muscle relaxants, particularly curare or other analogous agents targeted to the neuromuscular junction.


Sujets)
Animaux , Femelle , Mâle , Souris , Curare/administration et posologie , Curarisants non dépolarisants/administration et posologie , Consommation d'oxygène/effets des médicaments et des substances chimiques , Facteurs sexuels , Métabolisme basal/effets des médicaments et des substances chimiques , Température du corps/effets des médicaments et des substances chimiques , Rythme circadien/effets des médicaments et des substances chimiques , Curare/toxicité , Relation dose-effet des médicaments , Comportement alimentaire/effets des médicaments et des substances chimiques , Immobilisation , Estimation de Kaplan-Meier , Curarisants non dépolarisants/toxicité
SÉLECTION CITATIONS
Détails de la recherche