Cucarachas y vinchucas en patología general y respiratoria / Cockroaches abd vinchucas in general and respiratory pathology

Se exponen los datos sobre la antigenicidad de las proteasas de la cucaracha Periplaneta americana y de la vinchuca Triatoma infestans en seres humanos residentes en la CABA y Gran Buenos Aires, así como en las provincias del Norte y Noreste del país. La antigenicidad cruzada entre ambas las convierte en 2 insectos de gran importancia en el ecosistema, y sus restos momificados de estadios adultos y ninfales de trascendencia para diversas patologías infecciosas y respiratorias...

Data concerning the cross-reactivity between the serinproteases of the cockroach Periplaneta Americana and the reduviid Triatoma infestans are exposed. Humans living in Buenos Aires as well as those living in the north of the country inhale mummified particles containing the powerful antigens of both insects and develop chronic respiratory illnesses...

Murciélagos y ácaros en la alergia respiratoria / Bats and house-dust mites in respiratory allergy

Se valoró la posibilidad de que estos mamíferos ingirieron ácaros del hábitat (dermatophagoides pteronyssinus), y que sus antígenos formaran parte de las heces del murciélago (murcielaquina), y resultaren indirectamente alergénicos para los pacientes atópicos que habían revelado hipersensibilidad a dichas heces...

The possibility that house-dust mite antigens coming from dermatophagoides pteronyssinus were hidden in bat feces was studied in those atopic patients suffering rhinitis and asthma that revealed hypersensibility to bat feces...

Utilidad del VIC en la valoración de la funcionalidad de los linfocitos T / Usefulness of delayed-type hypersensitively skin tests, for the valoration of the functionality of the T-Lymphocytes

Data concerning the usefulness of delayed-type hypersensitivity skin tests with recall antigens are exposed. This easy technique has enormous value in the follow-up of the LT dependent immune competence frequently involved in several chronic diseses. We studied 464 patients with ages between 22 and 79 years old. Those 210 healthy controls revealed at least 4,24 ± 1,15 positive skin tests with 1409 ± 287 LTCD4+ cells meanwhile 135 HIV patients showed 2,02 ± 0,80 positive tests with 392 ± 83 LTCD4+ cells and 99 older subjects revealed 2,38 ± 1,15 with 720 ±154 LTCD4+ cells. Statistical differences between the groups were recorded.

Efecto de las hormonas tímicas sobre la síntesis de IL-4 / Effect of thymic hormones over the synthesis of IL-4

A thymic hormone baptized as thymostimulin coming from children aged between 5-10 years who died after car accidents was obtained by Sephadex G-50 column fractionation. This polypeptide was incubated with atopic and non-atopic human lymphocytes. The level of IL-4 in the supernatant was measured by ELISA. The atopic lymphocytes stimulated by the thymostimulin produced a great quantity of IL-4 (p>0.000001) in comparison with those coming from non-atopic patients. Thus, we postulate that thymic hormones should not be used in the treatment of allergic conditions with high levels of IL-4. The function of this polypeptide was compared with that of bovine timomodulin, which showed lower level of IL-4 (p>_ 0.001).

Patogenia e inmunoterapia en la sinusitis alérgica fúngica (SAF) / Pathogeny and immunotherapy of allergic fungal sinusitis

Allergic fungal sinusitis is an atopic condition close related to fungus allergens that initiate a chronic inflammation dependent of the IgE system and LTCD4-TH2 cells whose cytokines and chemokines induced the clinical symptoms. Specific immunotherapy is recommended to avoid the recurrences and to improve the benefits of the surgical procedures of the affected sinuses. We suggest that Bipolaris sp Drechslera sp extracts must be included in the skin testing of the atopic patients suffering rhinosinusal symptoms as well as those who reveal intense response to fungal allergens in general.