Résumé
Objective To study the effect of baicalin on the content of glutamate acid (Glu), aspartic acid (Asp), ?-aminobutyric acid (GABA) in the brain of rat with experimental intracerebral hemorrhage. Methods The intracerebral hemorrhage rat model was induced by collagen enzyme + heparin sodium. The rats were randomly divided into sham group, model group and high, middle, low dose group of baicalin. Rats were treated with the physiological saline and different concentration of baicalin respectively. The brain of each group was taken out three days later and the brain homogenate was prepared. The content of Glu, Asp and GABA was measured with the high performance liquid chromatography (HPLC). Results Compared with the sham group, the levels of Asp were obviously higher (P0.05) in each dose group of baicalin. Compared with the sham group, the contents of Glu were increased obviously (P
Résumé
Objective To observe the neuroprotection of Baicalin on brain damage following experimental intracerebral hemorrhage in rats.Methods Rat model of intracerebral hemorrhage was induced by collagenase method.The rats were randomly divided into sham operation control group,model group,high-,middle-and low-dose drug group,treated with different dose of Baicalin.The brain water content and the level of SOD,MDA,NO and NOS were measured at the third and seventh day after modeling repectively.Results Compared with the sham operation control group,the brain water content and the level of MDA,NO and NOS were significantly higher,and the level of SOD was significantly lower in model group.The brain water content and the level of MDA,NO and NOS were significantly lower,and the level of SOD was obviously higher in high-,middle-and low-dose Baicalin group than that in model group.Conclusion Baicalin has evident protective effect on brain damage after experimental intracerebral hemorrhage in rats,which maybe related to the increase of SOD and decrease of MDA,NO and NOS.