Multi-frequency magnetoencephalography study on alterations of resting-state neural networks in females with migraine at attack stage / 临床神经病学杂志

Objective To explore the alterations of resting-state neural networks in females with migraine at attack stage in low-and high-frequency ranges compared to healthy controls. Methods Resting-state magnetoencephalography data from 20 females with migraine ( migraine group ) and 20 age-and gender-matched healthy controls ( control group ) were collected to compute the neural network parameters through graph theory analysis.Independent samples t test was used to compare the difference of the network parameters between the two groups.The Pearson coefficient was used to assess the relationship between the abnormal network parameters and clinical manifestations of migraine.Results Compared with control group, females in migraine group at attack stage showed increased functional connectivity in the 0.1 -1 Hz, 4 -8 Hz, 12 -30 Hz, 30 -80 Hz band; increased shortest path length in the 80-250 Hz band; increased clustering coefficient and degree in the 0.1 -1 Hz band;decreased clustering coefficient and degree in the 4 -8 Hz, 12 -30 Hz band ( P<0.05 -0.01 ) .The functional connectivity of females with migraine at attack stage was positively correlated with number of years with migraine in the 12-30 Hz ( r=0.56, P=0.01 ) .Conclusion These results indicate that inherent neural networks are significantly impaired in low-and high-frequency ranges in females with migraine at attack stage and may contribute to the clinical manifestations of this disorder.

Efficacy evaluation of topiramate in treatment of patients with differe nt types of epilepsy / 中国临床药理学与治疗学

AIM: To evaluation the efficacy dosages of topiramate (TMP) in treatment of patients with different types of epilepsy. METHODS : The seizure rate in baseline phase of patients with epilepsy were observed and recorded before treatment of topiramate as monotherapy for 20 weeks. The TMP st arting dosage was 25 mg?d -1 , and then increased to 25 mg?d -1 each week for 8 weeks until effective dosage or 200 mg?d -1 for 12 weeks, and the change of seizure frequency and adverse reactions were recorded. RESULTS: The seizure in 31 cases ( 51.7 %) was totally contro lled, seizure reduction of ≥75% was in 14 cases ( 23.3 %), ≥50% was in 4 cas es ( 6.7 %), and