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Zhonghua zhong liu za zhi ; (12): 946-948, 2006.
Article de Chinois | WPRIM | ID: wpr-316260

RÉSUMÉ

<p><b>OBJECTIVE</b>To determine the maximum tolerated dose (MTU) and dose-limiting toxicity (DLT) of Docetaxel and Carboplatin in patients with non-small cell lung cancer.</p><p><b>METHODS</b>Docetaxel was given at escalating doses until MTD was determined from the initial dose of 65 mg/m2 to 75 mg/m2, 85 mg/ m2 on dl. Carboplatin was targeted to an area under the plasma concentration curve of 5 using Calver's equation on dl. The treatment cycle was repeated every 3 weeks.</p><p><b>RESULTS</b>16 patients received TXT and CBP for total of 54 courses (median four courses). Neutropenia was the dose-limiting toxicity. The MTD of TXT is 85 mg/m2.</p><p><b>CONCLUSION</b>We recommend TXT 75 mg/m2 on d1 and CBP with a target AUC of 5 on d1, 3weeks repeated for chemotherapy in naïve patients with NSCLC.</p>


Sujet(s)
Adulte , Sujet âgé , Femelle , Humains , Mâle , Adulte d'âge moyen , Protocoles de polychimiothérapie antinéoplasique , Utilisations thérapeutiques , Carboplatine , Carcinome pulmonaire non à petites cellules , Traitement médicamenteux , Calendrier d'administration des médicaments , Tumeurs du poumon , Traitement médicamenteux , Neutropénie , Induction de rémission , Taxoïdes
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