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Chinese Journal of Medical Genetics ; (6): 223-227, 2014.
Article Dans Chinois | WPRIM | ID: wpr-254477

Résumé

<p><b>OBJECTIVE</b>To identify pathological mutation in a Chinese male infant featuring oculocerebrorenal syndrome (also called Lowe syndrome).</p><p><b>METHODS</b>Clinical data of the patient were collected. DNA was extracted from peripheral blood of the infant and his parents. All of the 24 exons and intron-exon splice sites of OCRL gene were amplified with PCR. Mutations were detected by direct sequencing the PCR products.</p><p><b>RESULTS</b>The infant was found to have carried a c.1499G>A (p.R500Q) mutation in exon 15 of the OCRL gene, which was transmitted from his mother, who was heterozygous for the same mutation. The c.1499G>A mutation, discovered in Chinese population for the first time, has been reported to cause severe Lowe syndrome in other ethnic populations.</p><p><b>CONCLUSION</b>The c.1499G>A mutation of the OCRL gene is probably responsible for the disease in the patient. Further study of this mutation may facilitate delineation of the genotype-phenotype correlation of this disease.</p>


Sujets)
Humains , Nourrisson , Mâle , Mutation , Syndrome de Lowe , Génétique , Phosphoric monoester hydrolases , Génétique
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