Analysis of psychoacoustic characteristics and audiology tests of tinnitus patients with sensorineural hearing loss / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#Tried to find the relationship between tinnitus and each testing method, provided information for objective diagnosis and treatment for tinnitus patients with sensorineural hearing loss.@*METHOD@#The characteristics of audiology tests, including pure tone audiometric, acoustic immittance, middle ear muscle reflexes, matching test, distortion products otoacoustic emission(DPOAE) were compared in 79 ears of 69 tinnitus patients with sensorineural hearing loss.@*RESULT@#The RI positive rate was higher in Convergence curve in tinnitus patients of sensorineural hearing loss, with the rate being 51.3%. The detection rates of DPOAE were 15.2% in patients of sensorineural hearing loss tinnitus groups, which were significant lower than those in control group.@*CONCLUSION@#Psychoacoustic techniques can produce a useful amount of clinical data regarding tinnitus in different aspects, these data can help clinicians design needed based managements. DPOAE test is helpful for the diagnosis of lesions in some tinnitus patients.

Association of regulatory region of HLA-DPB1 with nasopharyngeal carcinoma in southern Chinese Hans / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To clarify the association between regulatory region of HLA-DPB1 (3'UTR) with Naso pharyngeal carcinoma in Guangdong Province Hans.@*METHOD@#The allelic types of HLA-DPB1-3'UTR were detected by sequence specific primer (SSP) in 104 patients with NPC and 105 control individuals from Guangdong Province Hans.@*RESULT@#The frequencies of allelic types B/B, haplotype B were higher in patients with NPC than those of the control individuals.@*CONCLUSION@#Positive association may exist between certain HLA-DPB1 alleles and NPC in Guangdong Province Hans.

Relationship between expression of inducible nitric oxide synthase in nasal mucosa and outcome after endoscopic sinus surgery / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To explore the role of the inducible nitric oxide synthase (iNOS) in the physiological mechanism of chronic rhinosinusitis (CRS), and to elucidate the relationship between the expression of iNOS in nasal mucosa and the outcome of endoscopic sinus surgery (ESS).@*METHOD@#Thirty-one patients of CRS were divided into two groups according to the levels of IgE in blood serum: Group A with high levels of serum TIgE (TIgE > or = 90 kU/L) and Group B with low levels of serum TIgE (TIgE < 90 kU/L). Immunohistochemical procedures were taken to determine the expression of iNOS in the nasal mucosa of each CRS patient, and the CT scans of sinuses were evaluated by the Lund-Mackay CT staging system. The time of the operative cavity epithelialized (OCE) was recorded by the unit of week. Associated between time of OCE and the the expression of iNOS or the CT staging was analyzed.@*RESULT@#The time of OCE was positive correlated with the expression of iNOS in Group A (P < 0.05) and did not show a clear correlation with the CT staging, while in Group B it was positive correlated with the CT staging (P < 0.05) and did not correlate with the expression of iNOS.@*CONCLUSION@#iNOS may be a predictive factor in the outcome of ESS. In cases of CRS patients with high levels of TIgE, time of OCE is positive correlated with the expression of iNOS in the nasal mucosa.

The management of the stoma in endoscopic dacryocystorhinostomy / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To explore the better management of the stoma in endoscopic dacryocystorhinostomy.@*METHOD@#To review the 102 chronic dacryocystitis patients (109 eyes), who underwent the endoscopic dacryocystorhinostomy surgery with silver clips used to maintain the stoma. They were given combined therapy after the surgery, and were followed up for a period range from 3-73 months.@*RESULT@#99/109 eyes (91%) were cured, 5/109 eyes (4.5%) were improved, and the total effective rate reached to 104/109 (95.5%).@*CONCLUSION@#The application of silver clip in endoscopy dacryocystorhinostomy surgery and combined therapy after the surgery can effectively prevent the stoma stenosis or atresia.