Résumé
Objective To analyze the influence of diagnosis and surgical treatment of spontaneous rupture and hemorrhage in patients with primary hepatic carcinoma(PHC) on prognosis.Methods 47 consecutive patients with spontaneous rupture and hemorrhage of HCC who had been admitted to our hospital from January 1998 to December 2004 were reviewed retrospectively and followed for 2 years.Results Among the 47 patients,41(87.23%) had liver cirrhosis and 44(93.6%) had been treated by operation. In those cases hepatectomy had been performed in 17 patients and 5 survived for 2 years.The death reasons in ruptured PHC are mainly hepatic function failure, renal function failure and gastrointestinal bleeding.Conclusion The prolonged survival could be achieved through accurately and timely diagnosis and treatment and the resection of the tumor is still a main measure for reducing the mortality in patients with ruptured PHC.
Résumé
Objective Study the effect of induced differentiation of abscisic acid (ABA) on human HCC cell line SMMC-7221.Methods Cultured SMMC-7221 cells were treated separately with RPMI-1640 culture medium, HMBA and ABA with different concentrations. Firstly, the appropriate concentration of ABA which inhibits SMMC-7221 cell proliferation was selected with the modified MTT method. Then electron microscopy was performed to observe the changes of microstructure. The cell cycle was analyzed by flow cytometry. Results Apart from 4?10 -4mmol/L concentration of ABA, the others could inhibit the cell proliferation. The inhibition rate increased with the time prolonging and the concentration increasing. The effect was most obvious with 4?10 -3mmol/L ABA. At this concentration the cells were arrested in G0/ G1 phase (P