Résumé
Zika virus (ZIKV) is closely related to severe neurological diseases such as neonatal microcephaly and GuillainBarre syndrome. As a new emergent infectious disease, the investigation on animal infection model of ZIKV has become a research hotspot. Establishment of animal infection models, an indispensable phase in drug and vaccine research and development, is of great significance to the study of viral pathogenesis and pathogen-host interaction. Based on the different diseases and adverse outcomes caused by the ZIKV infection, this paper reviews the current animal infection models of ZIKV and their applications in medical research, focusing on the lethal infection model, nervous system damage model and reproductive system damage model.
Résumé
The Chinese Food and Drug Administration issued the new Good Laboratory Practice(GLP)for nonclinical safety studies in September 2017,which emphasizes the peer review during the pathology practice.Pathology peer review could verify and im?prove the accuracy and quality of pathology diagnoses and interpretations in discussion.Pathology peer review is recommended when important risk assessment or business decisions are based on nonclinical studies.The objectives of this review are to provide a unified interpretation of the new regulation and recommend compliant processes for organizations to implement.