Résumé
It has been shown that the use of the combined therapy of Avlosulfone, Pyrazon, and Pyrifort produced encouraging results in the treatment of tuberculoid leprosy in reaction. Avlosulfone and Pyrifort acts directly on the causative organism while Pyrazon (calcium salt of phenylbutazone) acts as a host-reaction modifier. It is well-known that in the presence of lepra reaction, Avlosulfone may have to be withheld, specially if the reaction treatens to be severe. In so doing the active treatment is delayed while the reaction is being aborted. In spite of this, some reactions progress unabatingly, ignoring even steroid therapy. Not infrequently the steroids may have to be given for a long time to suppress the reaction and in so doing inevitably and unavoidably produced complications. Prollongation of severe reactions leads to serious sequelae some of which are scarring, contractures and atrophies, and trophic disturbances. Since most of the severe reactions to treatment are due to the host himself, the treatment of the disease requires not only the eradication of the bacillin but the solicitous management of the host as well. This paper has revealed an important finding-there promises to be a therapy which would treat leprosy and its reaction simultaneously. This paper however will not at this time make a definitive statement about the effectiveness of phenylbutazone. The author believes that more experiments on more patients are required. At this time, suffice it to be stated that in competent hands, the drug may well furnish the vehicle that will usher the leprologist on the threshold of another therapy in the management of lepra reactions. (Conclusion)