Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtrer
Plus de filtres








Gamme d'année
1.
Article de Anglais | WPRIM | ID: wpr-812542

RÉSUMÉ

Thymoquinone (TQ), an active component derived from the medial plant Nigella sativa, has been used for medical purposes for more than 2 000 years. Recent studies have reported that TQ blocked angiogenesis in animal model and reduced migration, adhesion, and invasion of glioblastoma cells. We have recently shown that TQ could exhibit a potent cytotoxic effect and induce apoptosis in mouse neuroblastoma (Neuro-2a) cells. In the present study, TQ treatment markedly decreased the adhesion and migration of Neuro-2a cells. TQ down-regulated MMP-2 and MMP-9 protein expression and mRNA levels and their activities. Furthermore, TQ significantly down-regulated the protein expression of transcription factor NF-κB (p65) but not significantly altered the expression of N-Myc. Taken together, our data indicated that TQ's inhibitory effect on the migration of Neuro-2a cells was mediated through the suppression of MMP-2 and MMP-9 expression, suggesting that TQ treatment can be a promising therapeutic strategy for human malignant neuroblastoma.


Sujet(s)
Animaux , Humains , Souris , Apoptose , Benzoquinones , Pharmacologie , Lignée cellulaire tumorale , Régulation négative , Matrix metalloproteinase 2 , Génétique , Métabolisme , Matrix metalloproteinase 9 , Génétique , Métabolisme , Neuroblastome , Traitement médicamenteux , Génétique , Nigella sativa , Chimie , Extraits de plantes , Pharmacologie
SÉLECTION CITATIONS
DÉTAIL DE RECHERCHE