Incidence of helicobacter pylori in dental plaque of Saudi gastritis patients

Helicobacter pylori [H. pylori] was identified in denial plaque, raising the possibility of future gastritis and peptic ulceration. This trial was to study the association between presence of H. pylori in dental plaque and in the stomachs of patients with gastritis; the effect of oral hygiene and periodontal condition on the stomach. Patients and Seventy-five Saudi adult dyspeptic patients, together with 60 healthy persons as control. Two samples of dental plaque were taken from gingival crevice of deepest pocket. One sample was kept in Christensen's urea agar and incubated for H. pylori detection by rapid urease test. The second sample was kept in 5% sheep blood agar, chocolate agar and a selective medium to culture the H. pylori. Gastric urease test was done for the same patients. [1] Plaque urease test results showed 89% positive patients. [2] Dental plaque Index: Mild dental plaque accumulation in 24%, moderate in 41%, while severe accumulation was in 35% of the patients. [3.] Gingival Index: Showed mild, moderate and severe gingivitis in 17%, 48% and 35% of patients, respectively. [4] Community periodontal index of treatment needs [CPITN]: Showed gingivitis, mild periodontitis and moderate periodontitis in 50%, 23% and 27% of patients, respectively. [5] Gastric urease 87% of patients were positive. [6] All cultured samples results were negative. The ability to detect H. pylori in dental plaque samples offers a potential for a noninvasive test for gastric infection and would lend support for oral spread of H. pylori as the principal mode of transmission. However, the presence of H. pylori in dental plaque and in the stomach [in gastritis patients] could permit not only a target for therapeutic procedures but also a monitoring tool for the efficacy of therapy

Clinical failure of ceftriaxone treatment in a patient with penicillin resistant pneumococcal meningitis.

A case of meningitis caused by penicillin resistant Strep.pneumoniae is described for the first time in our hospital. This case also showed treatment failure with Ceftriaxone. Patient was successfully treated with Imipenem. It is recommended that routine screening for penicillin resistance in meningeal isolates be done and in such instances, the MIC levels for third generation cephalo-sporins also be performed to detect resistance of any type