Résumé
Stress induced analgesia has been shown to utilise both non-opioidergic and opioidergic mechanisms. Earlier studies indicate that opiodergic analgesics exhibit corollary changes in blood glucose level. In this study, the changes in blood glucose level by swim induced stress and the influence of exogenous glucose administration on the stress induced antinociception were studied. Stress per se (both 30 sec and 3 min) did not modify the blood glucose level. However, exogenous administration of glucose reversed the stress induced antinociception in both non-opioid and opioid segments. Our results favour a role for glucose in stress induced analgesic activity.
Sujets)
Analgésie/psychologie , Animaux , Glycémie/métabolisme , Glucose/pharmacologie , Mâle , Souris , Douleur/traitement médicamenteux , Récepteurs aux opioïdes/effets des médicaments et des substances chimiques , Stress psychologique/complications , NatationRésumé
Impression cytology technique was used to study the cytological changes of in 30 patients with various diseases (Xerophthalmia, Steven-Johnson's syndrome, trachoma, alkali burns, kerato conjunctivitis sicca) resulting in dry eye syndrome. The main features of impression cytology were squamous metaplasia of epithelial cells and altered goblet cell density. The comparison between conjunctival biopsy findings and impression cytology confirm that impression cytology provides the same information as that of biopsy. Hence, the authors advocate that this non-invasive simple technique can replace conjunctival biopsy in confirmation of diagnosis in dry eye syndrome.
Sujets)
Adolescent , Adulte , Numération cellulaire , Enfant , Enfant d'âge préscolaire , Conjonctive/anatomopathologie , Syndromes de l'oeil sec/anatomopathologie , Femelle , Humains , Mâle , Adulte d'âge moyenSujets)
Adolescent , Adulte , Antibactériens/administration et posologie , Infections bactériennes/traitement médicamenteux , Enfant , Essais cliniques comme sujet , Ulcère de la cornée/traitement médicamenteux , Femelle , Humains , Mâle , Adulte d'âge moyen , Solutions ophtalmiques , Répartition aléatoireSujets)
Adolescent , Adulte , Enfant , Femelle , Humains , Kératite dendritique/anatomopathologie , Mâle , Adulte d'âge moyenRésumé
Estradiol-induced incorporation of radioactive uridine and leucine into the uterus of rat was inhibited by simultaneous treatment with an analogue of gonadotropin releasing hormone. The inhibitory action of gonadotropin releasing hormone was not mediated through modulation of estradiol receptor content. However, estradiol-induced increase in the level of poly(A) polymerase was inhibited by gonadotropin releasing hormone analogue, indicating that the inhibitory effect might involve post-transcriptional phenomenon.