Determination of salvianolic acid B and borneol in compound Danshen tablet by near-infrared spectroscopy and establishment of dependency model / 中国中药杂志

To determine the contents of salvianolic acid B and borneol in compound Danshen tablet (composed of Salviae Miltiorrhizae Radix et Rhizome, Notoginseng Radix et Rhizome and Borneolum Syntheticum) by near-infrared spectroscopy (NIR) and to establish a dependency model for rapid quantitative analysis. NIR data of 74 batches of compound Danshen tablet from different companies were collected; the contents of salvianolic acid B and borneol were determined by using high performanceliquid chromatography (HPLC) and gas chromatography (GC) respectively to establish the dependency model for salvianolic acid B and borneol. The results showed that the best waveband for salvianolic acid B was 10 846.2-10 013, 9 195.3-8 362.2, 6 719.1-4 242.8 cm⁻¹; root-mean-squares error of cross-validation (RMSECV), coefficient of determination ² and regression point displacement (RPD) of salvianolic acid B were 1.72 mg·g⁻¹, 91.05% and 7.93 mg·g⁻¹, respectively. While the best wavebands, RMSECV, ² and RPD of borneol were 10 846.2-5 060.5 cm⁻¹, 1.2 mg·g⁻¹, 96.11% and 6.71 mg·g⁻¹，respectively. The relative error of the established model as validation results for validation set samples was 2.67% and 4.64%， respectively.With the good predictability, the models can be applied to the real time monitoring and quality control of compound Danshen tablet.

Effects of acupoint thread implantation and Chinese herb on PTH and TGF-beta1 in the rate of chronic renal failure / 中国针灸

<p><b>OBJECTIVE</b>To probe into the mechanisms of thread implantation at Zusanli(ST 36) and Chinese herbs in treatment of chronic renal failure(CRF).</p><p><b>METHODS</b>CRF rat model was made by Platt subtotal nephrectomy. They were divided into 5 groups, sham operation group, model group, Chinese herbs group, thread implantation group and thread implantation plus Chinese herbs group. After treatment of 8 weeks, serum parathyroid hormone (PHT), transforming growth factor beta1 (TGF-beta1) expression in residual renal cells, malondialdehyde(MDA) content in the residual renal tissue, serum urea nitrogen(BUN) and creatinine(Scr), protein in urine and pathological changes were investigated.</p><p><b>RESULTS</b>The above indexes after treatment by thread implantation at acupoint, Chinese herbs, and acupoint thread implantation plus Chinese herbs showed begin reversion, especially, the most obviously improvement in the acupoint thread implantation plus Chinese herbs treatment group.</p><p><b>CONCLUSION</b>The mechanism of acupoint thread implantation and Chinese herbs in improvement of CRF is related with decrease of PTH, inhibition of TGF-beta1 expression, decrease of MDA content and resisting lesion of renal fibrosis.</p>

Effects of the volatile oil of Centipeda minima on acute pleural effusion in rats induced by an intrapleural injection of car / 中国中药杂志

<p><b>OBJECTIVE</b>To study the anti-inflammation effect of volatile oil of Centipeda minima and the mechanism of action.</p><p><b>METHOD</b>The animal model was induced by the Car injection into intrapleural of rats, to observe the effect of VOCM on acute inflammation.</p><p><b>RESULT</b>VOCM was able to inhibit the increase of NO, CRP and proinflammatory cytokines such as TNFalpha in the acute inflammation of the rat body.</p><p><b>CONCLUSION</b>VOCM has a protective effect on acute pleural effusion in rats induced by an intrapleural injection of Car.</p>

Studies on effects of xuedan on the experimental gastric ulcer / 中国中药杂志

<p><b>OBJECTIVE</b>To study the protective effects of Xuedan on the experimental gastric ulcer and the effects of anti-inflammatory, analgesic and bacteriostasis.</p><p><b>METHOD</b>The anti-gastric ulcer effects of Xuedan was investigated with gastric ulcer models induced by being immersed in cold water, having pylorus ligature and HAC injected into serous membrane in rats. The influence of gastric juice secrete in normal rats, the anti-inflammation action resulted from auricle swelling in mice, the analgesic action by mice body torsion method and the bacteriostotic effect in vitro were observed.</p><p><b>RESULT</b>Xuedan could reduce the ulcer area and decrease ulcer index, and gastric juice secrete. The hydrochloric acid in gastric juice and the activity of pepsin were reduced in rats. It could inhibit and disinfect Helicobacter pylori, lessen auricle swelling and the number of body torsion in mice.</p><p><b>CONCLUSION</b>Xuedan obvious preventive and treating effects on experimental gastric ulcer.</p>