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Indian J Physiol Pharmacol ; 2002 Jul; 46(3): 361-6
Article de Anglais | IMSEAR | ID: sea-106431

RÉSUMÉ

The present study was carried out to assess the lung functions in oral contraceptive administered women. Lung function tests were carried out with Spirometer (Vitallograph Compact II). A significant increase in vital capacity (VC) was observed in these women as compared to normal control. There was also a significant decrease in forced expiratory volume in 1 sec./vital capacity (FEV1/VC%) and forced expiratory volume in 1 sec./forced vital capacity (FEV1/FVC%) among oral contraceptive administered women as compared to controls. Further, a significant increase in peak expiratory flow rate (PEF), reduction in forced expiratory flow rate (FEF75-85%) and FEF75% were observed among oral contraceptive administered women as compared to controls. The increase in VC and PEF might be due to the synthetic form of progesterone (progestins) present in oral contraceptive pills which causes hyperventilatory changes. Synthetic progesterone during luteal phase of menstrual cycle might increase the static and dynamic volumes of lung i.e. VC and PEF. But FEF75% showed a decrease which might be due to the lower neuromuscular coordination during breathing.


Sujet(s)
Adulte , Indice de masse corporelle , Contraceptifs oraux synthétiques/effets indésirables , Éthinyloestradiol/effets indésirables , Femelle , Volume expiratoire maximal par seconde/effets des médicaments et des substances chimiques , Humains , Norgestrel/effets indésirables , Débit expiratoire de pointe/effets des médicaments et des substances chimiques , Tests de la fonction respiratoire , Phénomènes physiologiques respiratoires/effets des médicaments et des substances chimiques , Capacité vitale/effets des médicaments et des substances chimiques
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