Résumé
This paper reports the characterization of clinical Vibrio cholerae resistant to vibriostatic agent O/129, using classical and plasmid analysis. In a study conducted during December 1991-September 1993, two of 7,058 V. cholerae strains, obtained from patients suspected to have cholera in the State of Ceará, northeast Brazil, were resistant to 150 micrograms of the vibriostatic agent O/129 (2,4-diamino-6,7-diisopropylpteridine). One strain was identified as V. cholerae O1 El Tor Inaba and the other one as serogroup O22. Only one O1 strain harboured a plasmid of 147 kb transferable to Escherichia coli K12, and five strains of V. cholerae O1 and non-O1 were sensitive to O/129 and plasmid-negative at a frequency between 8 x 10(-2) and 3.6 x 10(-5). Additionally, O/129-resistant strains of V. cholerae O1 and O22 were resistant to trimethoprim/sulphamethoxazole.
Sujets)
Antibactériens/pharmacologie , Brésil , Choléra/microbiologie , Résistance microbienne aux médicaments , Entérite/microbiologie , Fèces/microbiologie , Humains , Ptéridines/pharmacologie , Vibrio cholerae/effets des médicaments et des substances chimiquesRésumé
Os autores apresentam um caso do Líquen plano ungueal com comprovação histopatológica- no qual, além das alterações clínicas habituais, houve associação de hiperpigmentação da lâmina. São discutidas as diversas manifestações do acometimento ungueal, a evolução peculiar do caso com melhora das alterações pigmentares, além de se proceder a uma breve revisão literatura