Résumé
O objetivo deste estudo foi testar o PM2.5 de São Paulo sobre o ECG, parâmetros hematológicos e histopatológicos de ratos saudáveis. Os animais receberam instilação de:salina, filtro branco, 100 e 500μg de PM2.5. O SDNN diminuiu 60 minutos após a instilação nos grupos de PM2.5 (p=0.025). Os reticulócitos aumentaram em ambas as doses de PM2.5 (p<0.05). Segmentados, neutrófilos e fibrinogênio diminuíram, enquanto que os linfócitos aumentaram com 100μg de PM2.5 (p<0.05) / The objective of this study was to test Sao Paulo PM2.5 on ECG, hematological and histopathological parameters of healthy rats. Animals received instillation of saline, blank filter, 100 and 500μg of PM2.5. SDNN decreased 60 minutes after instillation in PM2.5 groups (p=0.025). Reticulocytes significantly increased at both PM2.5 doses (p<0.05). Segmented, neutrophils and fibrinogen decreased, while lymphocytes increaseded with 100 μg of PM2.5 (p<0.05). A significant dose-dependent decrease of intra-acinar pulmonary arterioles Lumen/Wall ratio (L/W) was observed in PM groups (p<0.001). Peribronchiolar arterioles L/W showed a significant decrease in the 500μg group (p<0.001)...