Impact Of Pharmacist Intervention On Medication Knowledge And Adherence In Hemodialysis Patients

Objective: The objectives of the study are to evaluate the medication knowledge and medication adherence in patients undergoing haemodialysis and to educate the patients regarding the importance of medication adherence through counseling by providing Patient Information Leaflets and to analyze its impact. Methods: 50 Patients were randomly divided into two groups (control and test). Patient data was collected and documented using the patient data collection form after obtaining their consent. Their knowledge and medication adherence were assessed using questionnaires and was quantified. Patients included in the test group were counseled using Patient Information Leaflets whereas the control group was not counseled. Re-assessment was done during follow up for both groups. Results: Paired t-test was done to check if there was a significant difference in both the test and control group, with and without the use of Patient Information Leaflets respectively. The study showed that the test group had significant improvement (P<0.05) in their medication adherence and knowledge whereas there was no significant change in the control group. Conclusion: Providing patient counseling and continuous education with efforts to improve awareness among haemodialysis patients could enhance adherence to therapies and thus could improve clinical outcomes and quality of life.

Atividade hepatoprotetora dos extratos etanólico e hexânico das folhas de Momordica charantia / Hepatoprotective activity of hexane and ethanol extracts from Momordica charantia L. leaves

Momordica charantia L. (Cucurbitaceae) é empregada na medicina popular pelas diversas propriedades biológicas e farmacológicas. Neste trabalho, objetivou-se avaliar a atividade hepatoprotetora dos extratos hexânico (EH) e etanólico (EE) das folhas de M. charantia no modelo de lesão hepática aguda induzida pelo etanol. Em ambos os extratos foram detectados esteróides; EH apresentou atividade antioxidante mais marcante que EE. O pré-tratamento de camundongos (Swiss, machos) por via oral por três dias consecutivos com 25, 50 ou 100 mg Kg-1 de EH preveniu o aumento tanto de AST quanto de ALT (p<0,05) enquanto o pré-tratamento com EE preveniu apenas o aumento de ALT (p<0,05). Ambos os extratos reduziram a atividade das enzimas hepáticas, contudo EH apresentou efeito mais relevante, caracterizando potencial hepatoprotetor, possivelmente associado ao seu potencial antioxidante.

Momordica charantia L. (Cucurbitaceae) has been used in folk medicine based on its several biological and pharmacological properties. The aim of this work was to evaluate the hepatoprotective activity of hexane (HE) and ethanol (EE) extracts from M. charantia leaves on the acute liver injury model induced by ethanol. Steroids were detected in both extracts, and EH had higher antioxidant activity than EE. Oral pretreatment of male Swiss mice for three consecutive days with 25, 50 or 100 mg kg-1 HE prevented the increase in AST and ALT (p<0.05), whereas pretreatment with EE only prevented ALT increase (p<0.05). Both extracts reduced the activity of hepatic enzymes; however, HE had a more relevant effect, characterizing hepatoprotective potential, likely associated with its antioxidant potential.

Perfil hormonal da progesterona em ovelhas (Ovis aries) no início da gestaçäo, no pré-parto e início da lactaçäo / Evaluation of progesterone hormone profile on ewes at early pregnancy, preterm and early lactation

Foram utilizadas 15 ovelhas prenhes e em lactaçäo com o objetivo de se determinarem os padröes fisiológicos da progesterona, e de se verificar a presença ou näo de ritmo circadiano. Observou-se aumento crescente dos níveis de progesterona durante a gestaçäo, com diminuiçäo abrupta aos dois dias pré-parto. A análise de autocorrelaçäo revelou que esse hormônio apresentou no período de pré-parto ritmo circadiano muito mais evidente que no início da gestaçäo e lactaçäo