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Mem. Inst. Oswaldo Cruz ; 109(2): 154-162, abr. 2014. tab, graf
Article Dans Anglais | LILACS | ID: lil-705821

Résumé

Haematological and cytokine alterations in malaria are a broad and controversial subject in the literature. However, few studies have simultaneously evaluated various cytokines in a single patient group during the acute and convalescent phases of infection. The aim of this study was to sequentially characterise alterations in haematological patters and circulating plasma cytokine and chemokine levels in patients infected with Plasmodium vivax or Plasmodium falciparum from a Brazilian endemic area during the acute and convalescent phases of infection. During the acute phase, thrombocytopaenia, eosinopaenia, lymphopaenia and an increased number of band cells were observed in the majority of the patients. During the convalescent phase, the haematologic parameters returned to normal. During the acute phase, P. vivax and P. falciparum patients had significantly higher interleukin (IL)-6, IL-8, IL-17, interferon-γ, tumour necrosis factor (TNF)-α, macrophage inflammatory protein-1β and granulocyte-colony stimulating factor levels than controls and maintained high levels during the convalescent phase. IL-10 was detected at high concentrations during the acute phase, but returned to normal levels during the convalescent phase. Plasma IL-10 concentration was positively correlated with parasitaemia in P. vivax and P. falciparum-infected patients. The same was true for the TNF-α concentration in P. falciparum-infected patients. Finally, the haematological and cytokine profiles were similar between uncomplicated P. falciparum and P. vivax infections.


Sujets)
Adulte , Femelle , Humains , Mâle , Convalescence , Cytokines/sang , Paludisme à Plasmodium falciparum/sang , Paludisme à Plasmodium vivax/sang , Maladie aigüe , Brésil , Études cas-témoins , /sang , Chimiokines/sang , Facteur de stimulation des colonies de granulocytes/sang , Hématocrite , Inflammation , Interféron gamma/sang , Interleukine-1 bêta/sang , /sang , /sang , /sang , /sang , /sang , /sang , Paludisme à Plasmodium falciparum/immunologie , Paludisme à Plasmodium vivax/immunologie , Parasitémie , Plasmodium falciparum/isolement et purification , Plasmodium vivax/isolement et purification , Statistique non paramétrique , Facteur de nécrose tumorale alpha/sang
2.
Mem. Inst. Oswaldo Cruz ; 107(8): 1035-1041, Dec. 2012. graf
Article Dans Anglais | LILACS | ID: lil-660652

Résumé

The haematological changes and release of soluble mediators, particularly C-reactive protein (CRP) and nitric oxide (NO), during uncomplicated malaria have not been well studied, especially in Brazilian areas in which the disease is endemic. Therefore, the present study examined these factors in acute (day 0) and convalescent phase (day 15) patients infected with Plasmodium falciparum and Plasmodium vivax malaria in the Brazilian Amazon. Haematologic parameters were measured using automated cell counting, CRP levels were measured with ELISA and NO plasma levels were measured by the Griess reaction. Our data indicate that individuals with uncomplicated P. vivax and P. falciparum infection presented similar inflammatory profiles with respect to white blood cells, with high band cell production and a considerable degree of thrombocytopaenia during the acute phase of infection. Higher CRP levels were detected in acute P. vivax infection than in acute P. falciparum infection, while higher NO was detected in patients with acute and convalescent P. falciparum infections. Although changes in these mediators cannot predict malaria infection, the haematological aspects associated with malaria infection, especially the roles of platelets and band cells, need to be investigated further.


Sujets)
Adulte , Femelle , Humains , Mâle , Plaquettes/immunologie , Protéine C-réactive/analyse , Médiateurs de l'inflammation/sang , Paludisme à Plasmodium falciparum/sang , Paludisme à Plasmodium vivax/sang , Granulocytes neutrophiles/immunologie , Monoxyde d'azote/sang , Maladie aigüe , Convalescence , Test ELISA , Paludisme à Plasmodium falciparum/diagnostic , Paludisme à Plasmodium falciparum/immunologie , Paludisme à Plasmodium vivax/diagnostic , Paludisme à Plasmodium vivax/immunologie
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