Résumé
Effects of medroxy progesterone acetate (MPA; 5 mg/kg) and MPA + testosterone enanthate (TE) (3 mg + 2 mg/kg) were investigated in vas deferens and on fertility (along with reversibility study) for 60 days through histopathology, morphometric and certain biochemical parameters such as total proteins, sialic acid, ATPase, SDH and testosterone. The study revealed for altered histopathology and contratile pattern of vas deferens resulting in reduced fertility. The study also indicated androgen antagonistic effect. These effects were found to be reversible 4 and 3 months after withdrawal of MPA and MPA + TE injections respectively. Thus, both types generated functional sterility in the rat, but MPA affected histophysiology of vasal tissue.
Sujets)
Animaux , Fécondité/effets des médicaments et des substances chimiques , Mâle , Acétate de médroxyprogestérone/pharmacologie , Contraction musculaire/effets des médicaments et des substances chimiques , Rats , Numération des spermatozoïdes/effets des médicaments et des substances chimiques , Mobilité des spermatozoïdes/effets des médicaments et des substances chimiques , Testostérone/analogues et dérivés , Conduit déférent/effets des médicaments et des substances chimiquesRésumé
Bimonthly injections (im) of medroxyprogesterone acetate (MPA, 5 mg/0.2 ml) and testosterone enanthate (TE, 2.5 mg/0.2 ml) to rats for 30 and 60 days induced oligospermia. The sperms from epididymis had defective metabolism, alterations in their morphology, viability and acrosome integrity. Thus this altered sperm function resulted in reduction in the fertility rate of MPA+TE treated animals.