Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtre
Ajouter des filtres








Gamme d'année
1.
China Journal of Chinese Materia Medica ; (24): 628-631, 2008.
Article Dans Chinois | WPRIM | ID: wpr-284375

Résumé

<p><b>OBJECTIVE</b>To study scutellaria thermosensitive gel in situ.</p><p><b>METHOD</b>The phase transition temperature of gel with various concentration polymer solutions was studied by using stirring method and the viscosity of gel was monitored under different temperatures. Eye irritation experiments were performed with rabbit. The duration of residence time in rabbit eyes of scutellaria thermosensitive gel was observed with 2% fluorescein.</p><p><b>RESULT</b>20% poloxmar407 and 10% poloxmar 188 were suitable to scutellaria thermosen-sitive gel in situ. The results suggested that the scutellaria thermosensitive gel in situ based on poloxmar were nonirritant and retention time on the surface of eye was (150 +/- 8) min.</p><p><b>CONCLUSION</b>The scutellaria thermosensitive gel in situ forms gel in eye and has longer release time than that of eye drops.</p>


Sujets)
Animaux , Femelle , Mâle , Lapins , Médicaments issus de plantes chinoises , Chimie , Métabolisme , Toxicité , Oeil , Gels , Solutions ophtalmiques , Métabolisme , Poloxamère , Chimie , Scutellaria , Chimie , Métabolisme , Toxicité , Sensibilité et spécificité , Facteurs temps , Température de transition
SÉLECTION CITATIONS
Détails de la recherche