Advance in relationship between autophay and tumor / 国际外科学杂志

Autophagy is known as cellular degradation of long-lived proteins and organelles, by a double-membranound structure fusing with the lysosome, for recycling intraceUular constituents and reusing nutri-tion. Defective autophagy is closely correlated with tumorigenesis and tumor progress. There are crosstalks between autophay associated/regulative genes and oncogene/anti-oncogene. More over, regulative autophagic cell death may lead to an novol way for cancer therapy.