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Acta cir. bras ; 33(6): 483-490, June 2018. tab, graf
Article Dans Anglais | LILACS | ID: biblio-949354

Résumé

Abstract Purpose: To evaluate the effects of hypothermia treatment on meconium-induced inflammation. Methods: Fifteen rats were instilled with human meconium (MEC, 1.5 mL/kg, 65 mg/mL) intratracheally and ventilated for 3 hours. Eight rats that were ventilated and not instilled with meconium served as a sham group. In MEC-hypothermia group, the body temperature was lowered to 33±0.5°C. Analysis of the blood gases, interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α in bronchoalveolar lavage (BAL) fluid samples, and histological analyses of the lungs were performed. Results: The BAL fluid TNF-α, IL-1β, IL-6 and IL-8 concentrations were significantly higher in the MEC-hypothermia group than in the MEC-normothermia (p < 0.001, p < 0.001, p = 0.001, p < 0.001, respectively) and sham-controlled groups (p < 0.001, p < 0.001, p < 0.001, p < 0.001, respectively). Conclusion: Meconium-induced inflammatory cytokine production is affected by the body temperature control.


Sujets)
Animaux , Mâle , Pneumopathie infectieuse/anatomopathologie , Syndrome d'aspiration méconiale/anatomopathologie , Syndrome d'aspiration méconiale/thérapie , Hypothermie provoquée/méthodes , Pneumopathie infectieuse/métabolisme , Pneumopathie infectieuse/thérapie , Test ELISA , Liquide de lavage bronchoalvéolaire/composition chimique , Syndrome d'aspiration méconiale/métabolisme , Reproductibilité des résultats , Interleukine-8/métabolisme , Interleukine-6/métabolisme , Facteur de nécrose tumorale alpha/métabolisme , Résultat thérapeutique , Rat Wistar , Modèles animaux de maladie humaine , Interleukine-1 bêta/métabolisme , Mesures de luminescence/méthodes , Poumon/anatomopathologie
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