Epidemiology of genito-urinary tumors in Qatar

A retrospective review of genito-urinary tumors examined histopathologically in Qatar during the period 1998-2004 showed bladder cancer to be the most common followed by prostate, renal, testicular, renal pelvis and urethral tumours in order of decreasing prevalence. The apparent increasing annual prevalence of some tumors is discussed and the findings are compared with those reported from neighbouring countries and in literature from the West

Microbiological transformation of diclofenac

Microbiological transformation of diclofenac has been investigated using nineteen microbial species. The study showed that most organisms metabolized diclofenac sodium to different extents, to yield three metabolites that were identified by 2D NMR and MS analyses. The major metabolite was found to be 4hydroxydiclofenac while the other two were 5-hydroxydiclofenac and 4hydroxydiclofenac lactam. The three metabolites were also obtained as mammalian metabolites of diclofenac sodium, lending further support to the concept of microbial models of mammalian drug metabolism