RÉSUMÉ
An In Vivo attempt to induce psoriatic lesions in the skin of BALB/C mice by injection of bacterial superantigen. Staphylococcus aureus that was isolated from skin lesions of psoriatic patients was subjected to gel filtration chromatography for extraction and purification of their exoproteins. The skin of BALB/C mice was injected by 0.2 ml of the extracted purified exo toxin. The induced lesions were markedly similar to that of human psoriatic lesions, although the histopathological changes were not completely mirrored to that of human psoriatic skin lesions. There is an important role of Staph. aureus exotoxin [superantigen] in induction, triggering and maintenance of psoriatic lesions
Sujet(s)
Animaux de laboratoire , Staphylococcus aureus/immunologie , Superantigènes/biosynthèse , Toxines bactériennes , Souris de lignée BALB C , Modèles animauxRÉSUMÉ
From a total of 286 cases ofAtopic Dermatitis [AD] patients, 94.4% and 86.36% yielded positive cultures of eczematous lesions and healthy area of AD skin. Twenty various bacterial types and a total of 959 and 744 isolates were identified from each of above areas respectively. Staph. aureus was the predominant bacterial agent isolated from 60.48% of eczematous lesions, while Staph. epidermidis was predominantly from 57.34% of healthy areas of AD patients [P< 0.001]. The bacterial numbers ranged from [0.02-92.0]x10[5] cell/cm[2] in eczematous lesions and [0.11-23.0]x 10[3] cell/cm[2] in healthy areas of atopic skin [P< 0.001]
Sujet(s)
Humains , Mâle , Femelle , Eczéma atopique/immunologie , Allergènes/immunologie , Staphylococcus , Peau/microbiologie , EczémaRÉSUMÉ
Determination of concentrations of cluster of differentiation [CD] markers in patients with atopic dermatitis and comparison with healthy individuals were carried out in this study. It was found that the mean concentrations of positive lymphocytes for AD patients reached 82.2%, 55.7%, 28.7%, and 21.9% for CD3, CD4, Cd8, and GD19, respectively, and those of healthy individuals reached 72.2, 40.3, 18.5, and 13.1 for CD3, CD4, Cd8, and CD19 respectively. We found that the mean values of CDs for AD patients high than those of healthy individuals [69.7%, 75.9%, 94.4% and 68.5%] [P<0.05]
re high than those of healthy individuals [65.7%, 75.9%, 94.4% and 68.5%] [P<0.05]
Sujet(s)
Humains , Antigènes CD , Immunophénotypage , Antigènes CD3 , Antigènes CD4 , Antigènes CD8 , Antigènes CD19RÉSUMÉ
A community-based seroepidemiological study was made of 4 common zoonotic infections [brucellosis, hydatidosis, toxoplasmosis and visceral leishmaniasis] in 3 areas [rural, urban and suburban semirural] in Basra governorate, southern Iraq. The prevalence of brucellosis was higher in the suburban semirural area [29.3%] than the rural and urban areas. The prevalence of hydatidosis [19.0%-35.5%] and toxoplasmosis [41.1%-52.1%] were relatively high in all 3 areas. With respect to visceral leishmaniasis, low rates of infection were reported [0.2%-1.9%]. The study shows in general that the suburban semirural area is at highest risk of zoonotic infections compared with other areas. The results could form a rational basis for the planning of an integrated comprehensive approach for control of zoonotic infections in the areas surveyed
Sujet(s)
Animaux , Humains , Leishmaniose/épidémiologie , Toxoplasmose/épidémiologie , Population urbaine , Population rurale , Prévalence , Études séroépidémiologiquesRÉSUMÉ
Outline the hearing and cognitive profile of children with Down syndrome in relation to speech and language aptitudes in order to recognize other underlying etiological factors of communicative disability beside mental handicap that would improve the rehabilitation of those children. Twenty children with Down syndrome and 20 age and sex-matched normal subjects were subjected to comprehensive audiological evaluation including pure tone audiometry, tympanometry, Auditory brainstem response [ABR], and Event-related potentials [ERPs] in addition to vocal tract examination, and communicative and psychometric evaluation. Conductive hearing loss was detected in 5 [25%] as a complication of recurrent otitis media and repeated insertion of ventilation tubes. ABR wave V detection thresholds were compatible with behavioural pure tone audiometry. Shortened absolute latency of waves I, III and V as well as interpeak latency of I-III, III-V and I-V was observed in 10 patients [50%]. In 8 patients [40%] ERPs showed delay in latency of N[1], P[2], N[2] and P[3] components. In comparison to normal subjects, all patients showed variable degrees of subnormal mentality and social immaturity [p<0.001] as well as delayed language [language age] development [p<0.001]. Auditory dysfunction in patients with Down syndrome can occur at many levels either middle ear, brainstem and higher cortical cognitive progressing. Such findings may contribute to lower functioning of those patients in cognitive, linguistic and social aptitudes. Early audiological screening specific management and well-tailored rehabilitation strategy may allow improved prognosis and good quality of life in patients with Down syndrome
Sujet(s)
Humains , Mâle , Femelle , Troubles de la cognition , Tests auditifs , Enfant , Potentiels évoqués auditifs , Audiométrie , Surdité de transmission , Troubles de la communication , RéadaptationRÉSUMÉ
The aim of this study was to determine the prevalence of GJB2 and 12S rRNA mutations in Egyptian families with hereditary hearing loss. Twenty three families showing hereditary hearing loss analyzed. Seventeen of these families showed non-syndromic sensorineural hearing loss while the rest 4 families were showing syndromic form of hearing loss. All subjected were examined by clinical evaluation and genetic analysis of their samples, including PCR, restriction assays, sequencing and SSCP. The 35 delG was found in 23.53% [4/17] of the families or in 24 of 242 [16.9%] investigated alleles. Four patients were heterozygous carriers and 10 patients were homozygous for the 35 delG mutations. No other mutations of GJB2 have been reported. No A155G mutation have been detected in the study group. These results emphasize the importance of genetic diagnosis and genetic counseling of deaf patients in Egypt
Sujet(s)
Humains , Mâle , Femelle , Fréquence d'allèle , Réaction de polymérisation en chaîne , Mutation , Conseil génétique , Famille , Audiométrie , ADN , Allèles , Connexines , ARN ribosomique , Perte d'audition/congénitalRÉSUMÉ
To identify the effect of noise in the NICU on neonate's hearing status, and to assess the value of using hearing protectors [e.g. earplug and earmuff] to minimize the effect of noise on these neonates. '634' newborns were divided into two groups, the control group [n = 395] and the study [n = 239]. The noise level inside and outside incubators was measured by using sound level meter. Neonates in both groups were tested for hearing by transient evoked otocacoustic emissions [TEOAE] test on admission. The study group of neonates worn ear protectors from admission to discharge while the control group did not. Transient Evoked Otoacoustic Emission test was repeated for both groups on discharge. Any infant who didn't pass the test on discharge was reevaluated 2 months later and in case of new failure, the test was repeated at 4 months of the infant's age. Statistically significant differences were found between infants in both groups regarding TEOAE test results either at discharge or at the first follow with a higher percentage of failed tests among infants in the unprotected control group. Also, the prevalence of failed ear response was higher in neonates were exposed to noise 45 dB or more than those exposed to noise level < 45 dB. It was noticed that mean duration of hospital stays was shorter in the study group than in the control group [8.9 VS 13.7]. Environmental noise in the NICU has potential adverse effect on neonate's hearing status. Noise induced hearing loss in NICU is mostly transient and reversible. Using ear protectors were useful in reducing the hazardous effect of noise on hearing sense in neonates in NICU
Sujet(s)
Humains , Mâle , Femelle , Nouveau-né , Unités de soins intensifs néonatals , Dispositifs de protection des oreilles , Potentiels évoqués auditifs , Bruit , Surdité due au bruitRÉSUMÉ
To investigate clinical aspects and aetiological agents of osteomyelitis with special emphasis on anaerobic infection. Setting: Basrah University Teaching Hospital, Iraq. Design: A prospective study. Aerobic and anaerobic cultures were made for all cases. The inoculation of operative material on culture media was performed by the bedside. The study included 134 patients with osteomyelitis. The cases were divided clinically into 4 main groups: haematogenous, exogenous, postoperative and mastoiditis. Staphylococcus aureus was the most common causative agent in haematogenous osteomyelitis whereas Pseudomonas sp. were the most common causative organisms in postoperative and mastoiditis groups of bone infection. The total number of isolated bacteria was 224, of which 50 [22%] were anaerobes. These anaerobes were isolated from 39 [29%] of 134 patients. The anaerobic organisms were found most frequently in the cases of chronic mastoiditis [57%] and erogenous osteomyelitis [40%]. High prevalence rate of anaerobic bone infection was found specially in chronic cases. Thus, conventional treatment measures may not be beneficial and special type of management should be applied for these cases. Anaerobic culture is also recommended for all cases with osteomyelitis
Sujet(s)
Humains , Mâle , Femelle , Ostéomyélite/microbiologie , Ostéomyélite/épidémiologie , Ostéomyélite/étiologieRÉSUMÉ
We trace the evidence-based evolution of ureaplasmal male infertility as an established clinical entity. We review epidemiology data, possible pathogenic mechanisms of Ureaplasma urealyficurn in infertility, and the results of isolation studies and therapeutic trials. Future developments are outlined
Sujet(s)
Humains , Mâle , Infections à Mycoplasma , Infections à Ureaplasma , Mycoplasma/pathogénicitéRÉSUMÉ
Evaluation of hearing acuity using the conventional pure-tone audiometry was performed in 48 patients less than 40 years of age as well as 15 age and sex matched healthy subjects as controls [group I]. Twenty-two patients were treated conservatively [group II] and twenty-six patients on regular hemodialysis HD [group III] who were further classified according to the duration of HD into fourteen patients dialyzed for
Sujet(s)
Humains , Mâle , Femelle , Surdité neurosensorielle , Tests auditifs/méthodes , Audiométrie électroencéphalographique , Dialyse rénale/effets indésirables , AudiométrieRÉSUMÉ
This study was designed to examine factors which can affect early identification of hearing loss in children of Upper Egypt. The medical records of 252 children with significant hearing loss were studied. Information about each child's degree and type of hearing loss, cause of hearing loss, source of referral, additional handicaps, age of suspicion of loss, age of identification and time of hearing aid fitting were collected. Children with a greater degree of hearing loss, additional medical problem or additional handicap were identified earlier than those without these factors. In addition, children with positive family history of hearing loss were also detected earlier than those with negative family history. This study showed that hearing impaired children in Upper Egypt were identified and fitted with hearing aids at age older than that recommended for proper rehabilitation
Sujet(s)
Humains , Surdité , Troubles de l'audition/diagnostic , EnfantRÉSUMÉ
The prevalence and role of anaerobic bacteria in bone infection were investigated in this prospective study on 134 cases with pyogenic osteomyelitis. Specimens were inoculated immediately in the operating theatre or in the ward and incubated under aerobic and anaerobic conditions without using transport media. Anaerobic organisms were isolated from 39 of the 134 cases [29%] of all types of pyogenic osteomyelitis. The total number of aerobic and anaerobic isolates was 224, of which 50 were anaerobes [22%]. Syringe-aspirated specimens were better than swab specimens for the isolation of anaerobes. Anaerobes were mostly isolated from osteomyelitis cases of long duration
Sujet(s)
Bactéries anaérobies/pathogénicité , Bactéries anaérobies/isolement et purification , Maladies osseuses/microbiologieRÉSUMÉ
Taenia saginata infections are difficult to cure completely. Drugs such as niclosimide, aminosidine, atebrine and the introduction of a large volume of hot water with a cathartic through a duodenal tube can be useful in the treatment but does not always lead to expulsion of the tapeworm and can have serious toxic effects on the host. Gastrografin [an inert nontoxic radio-opaque substance] was used to show the number, shape and position of taenia saginata parasite. Unexpectedly, after intraduodenal injection of gastrografin, the parasite was expelled lower with its scolex through the anus. Fifteen children with taenia saginata infection diagnosed by stools examination for ova and visualisation of the motile segments of the parasite, were given gastrografin orally in two successive doses of 100 ml and 200 ml three hours apart. The whole parasite with its scolex was expelled intact through the anus after six hours in ten patients and within twenty-four hours in five cases. No dehydration or other serious adverse effects were observed in any of the cases. Gastrografin proved to be used safely in treatment of taenia saginata infection without complications