Résumé
The present study was carried out to assess the hepatoprotective activity of leaves of Erythrina indica against carbon tetra chloride-induced hepatotoxicity in rats. Albino rats of both sexes weighing 150-250 gm were used for the study. Alcohol and Ethyl acetate extracts of leaves of Erythrina indica at a concentration of 250 mg/kg were studied by using Silymarin [200 mg/kg] as reference standard. All the test drugs were administered along with 0.5 ml carbon tetra chloride for four days through intraperitoneal route. The level of marker enzymes SCOT, SGPT and Alkaline Phosphatase and histopathalogical studies were carried out for ascertaining the protective activity of the extracts. Both alcoholic and ethyl acetate extract lowered the elevated SCOT and SGPT level. Histopathalogical studies showed the absence of necrosis as compared to carbon tetra chloride treated animals. These observations revealed that alcohol and ethyl acetate extracts of leaves of Erythrina indica at the concentration of 250 mg/kg possess hepatoprotective activity against carbon tetra chloride-induced hepatotoxicity in rats