School desk and chair design based on high school female students anthropometry Qazvin, Iran 2007 to 2008

Anthropometry data compiled from body dimensions of female high school students are used to optimize the design of desks and chairs for the classrooms of these students. It is necessary to design suitable desk/chair based on anthropometry data in order to reduce musculoskeletal, visual, circulatory problems, and bad posture during long hours of studying. The goal of this study is to design desks/chairs based on the standard BS 5873 using the body dimensions of 240 female high school students. 240 female students, between the ages of 15 to 17 years old were selected from six different high schools in district 2 of city of Qazvin in Iran. Data for this study were gathered using an interview method and anthropometry measurement devices. Eighteen body dimension parameters of 240 female high school students were obtained. The collected data were analyzed and compared to the standard using SPSS methods. The participant students were divided into 2 groups and customized desk/chair designs were built to fit their body dimensions. There is a significant difference between each customized desk and chair dimension, and standard dimensions used in the industry with an exception of the heights of these designs. We suggest that customized designs based on body dimensions promote correct posture, comfort and health

[Experimental production and initial imaging of [18 F]-14-Fluoro-6-thia-hepatadecanoic acid [[18F]-FTHA] for myocardial performance]

[18F]-6-thia-14-fluoro-heptadecanoic acid 3b, a free fatty acid, has been used in myocardial PET imaging. In order to establish an automated synthesis module for routine production in the country, a study performed for optimization of the production conditions as well as making modifications. [18F] Benzyl-14-Fluoro-6-thia-heptadecanoate 2b was prepared in no-carrier-added [n.c.a] form from C in Benzyl-14-tosyloxy-6-thia-heptadecanoate 1 in one step at 90 Kryptofix2.2.2/[18F] and acetonitrile as the solvent followed by Silica column chromatography. The radiolabeled ester 2 was then hydrolyzed to yield [18F]-6-thia-14-fluoro-heptadecanoic 3b. The final solution was concentrated using C18 SPE system and administered to normal rats for biodistribution as well as co-incidence imaging studies. The synthesis took 15 min with overall radiochemical yield of 15-25% [EOS] and chemical-radiochemical purity more than 94%. Automation was performed using a two-pot synthesis. The best imaging time was shown to be 140-180 minutes post injection. Using this procedure a fast, reliable, automated synthesis for the cordial PET tracer, i.e. [18F]-FTHA can be obtained without HPLC purification step

Preparation, distribution, stability and tumor imaging properties of [62 Zn] bleomycin complex in normal and tumor - bearing mice

Bleomycin [BLM] has been labeled with radioisotopes and widely used in therapy and diagnosis. In this study BLM was labeled with [62Zn] zinc chloride for oncologic PET studies. The complex was obtained at the pH=2 in normal saline at 90°C in 60 min. Radio-TLC showed an overall radiochemical yield of 95-97% [radiochemical purity > 97%]. Stability of complex was checked in vitro in mice and human plasma/urine. Preliminary in vivo studies performed to determine complex stability and distribution of [62Zn] BLM in normal and fibrosarcoma-bearing mice. [62Zn] BLM accumulated significantly in induced fibrosarcoma tumors in mice according to bio-distribution/imaging studies. [62Zn] BLM can be used in PET oncology studies due to its suitable physico-chemical properties as a diagnostic complex in vitro and in vivo. Further studies should be performed for evaluation of the complex behavior in higher animals