Utility of imidazole derivative in the synthesis of biologically active nitrogen heterocyclic systems

Reaction of 2-[4-[4-Chlorobenzylidene]-5-oxo-4,5 dihydroxazol2-ylmethyl]- isoindole-l,3-dione [1] with p-aminoacetophenone followed by reaction with p-chi- orobenzaldehyde afforded chalcone 3, which used was as a precursor for the synthesis of a variety of pyrazole, oxazole, pyrimidine, pyridine and oxarine compounds.On the other hand, the reaction of 1 with glycine afforded imidazolylglycine [14] which reacted with thionyl chloride followed by addition of ammonium thiocyanate to give the isothiocyanate derivative 15 which reacts with different nitrogen and carbon nucleophiles to afford new derivatives of biologically active heterocycles. The antimicrobial activities of some synthesized derivatives were examined against some selected bacteria and fungi

Synthesis and biological activity of 3,5-disubstituted rhodamines, part IV

Substituted rhodanines [Ia-c] with halo compounds aromatic aldehydes, ketones, anhydrides and amines to afford compounds [II-V]a-c. The antibacterial activities of all synthesized derivatives has been investigated

Reactions and biological activity of substituted quinolone

Substituted quinoline reacted with halo compounds, amino acids, urea, amides, anilides and hydroazines. All the synthesized derivatives were biologically investigated. The quinoline chemistry with its diverse biological properties like antihistaminic, antihelminthic has got much importance in recent years as chemotherapeutic drugs