Effects of metiamide and proglumide on gastric acid secretion in rats

The effects of metiamide and proglumide on hydrochloric acid secretions have been studied. Metiamide and proglumide antagonized the effects of the histamine on the gastric hydrochloric acid secretion

Effect of adrenaline and nor adrenaline on insolated ratureter preparations

The effect of adrenaline and non-adrenaline on the spontaneously contracting and quiescent isolated proximal and central pieces of ureters obtained from female [virgin] albino rats of the Sprague Dawley strain were studied. Adrenaline and nor-adrenaline produced a stimulant effect on the rate and amplitude of the proximal pieces of spontaneously contracting preparations. Both these drugs induced persistaltic activity in similar quiescent preparations. Adrenaline also produced a stimulant effect on the spontaneously contracting preparations of the central portions of the ureters. In view of these findings it is suggested that as far as the responses to adrenaline and nor-adrenaline are concerned, the proximal and the central portions of the isolated rat ureter preparations behave as if they possess a preponderance of alpha [excitatory] adrenergic receptors