Résumé
In this study, a comparative investigation was performed to assess the performance of hydrogenated phosphatidyl choline [HPC] and cellulosic polymers as ethyl cellulose [EC] and hydroxypropylmethyl-cellulose [HPMC] as matrix-forming agents. Indomethacin was used as a model drug for the preparation of these controlled release tablets. Tablets were evaluated for their compaction characteristics and in vitro drug release behavior. Direct compression [DC] and wet granulation [WG] techniques were used to prepare the tablets. Magnesium stearate was the lubricant, avicel and lactose were the vehicles, while HPC and the cellulosic polymers served as retarding agents. The dissolution rates of these tablets were controlled by USPXXII dissolution method and the profile of each tablet formulation was plotted. WG technique was successful in using these retarding agents to sustain the release of the drug