Lymphoma survey: a collective experience in the Greater Manila Area

123 cases of malignant lymphoma with histologic documentation were reviewed from the files of four contributors from the newly organized Philippine Board of Medical Oncology. Twenty-seven cases of HL and 96 cases of NHL were analyzed according to age, sex, geopgraphic distribution, clinical staging , clinical features, response to therapy, survival time in relation to stage and response to therapy, and non-medical factors which directly affect the prognosis. Multiple drug therapy consisting mainly or cyclophosphamide, vincristine and prednisone were utilized; nitrogen mustard, chlorambucil and mitomycin were also used. Prognosis was good, compatible with long term survival, especially in those who had adequate, continuing therapy. (Summary)

Chemotherapy of cancer mitomycin-C

75 patients with cancer were treated with Mitomycin-C, of which only 54 had evaluable results. Over-all response rate was 25/54 (48%) divided according to primary sites as colonic and small intestinal - 4/13 responses, breast - 5/9, liver - 3/4, gastric - 3/4, pancreatic - 2/4, gallbladder - 2/2, esophageal - 1/2, nasopharyngeal - 1/2, parotid - 1/1 and a case each of chondrosarcoma, rhabddomyosarcoma, mesothelioma, urinary bladder carcinoma, and reticulum cell sarcoma with no responsesMinor side-effects were anorexia (33%), nausea (33%), vomiting (20%), lassitude (20%) epilation (10%) and chills and fever (2.5% each). Major side-effects were leucopenia (11%) anemia (5.5%) and thrombocytopenia (4%). In the three of the patients with myelosuppression secondary to Mitomycin C, blood transfusions of 2 to 4 pints were administered because of moderate anemia. (Summary)