RÉSUMÉ
Exercise training (Ex) has been recommended for its beneficial effects in hypertensive states. The present study evaluated the time-course effects of Ex without workload on mean arterial pressure (MAP), reflex bradycardia, cardiac and renal histology, and oxidative stress in two-kidney, one-clip (2K1C) hypertensive rats. Male Fischer rats (10 weeks old; 150–180 g) underwent surgery (2K1C or SHAM) and were subsequently divided into a sedentary (SED) group and Ex group (swimming 1 h/day, 5 days/week for 2, 4, 6, 8, or 10 weeks). Until week 4, Ex decreased MAP, increased reflex bradycardia, prevented concentric hypertrophy, reduced collagen deposition in the myocardium and kidneys, decreased the level of thiobarbituric acid-reactive substances (TBARS) in the left ventricle, and increased the catalase (CAT) activity in the left ventricle and both kidneys. From week 6 to week 10, however, MAP and reflex bradycardia in 2K1C Ex rats became similar to those in 2K1C SED rats. Ex effectively reduced heart rate and prevented collagen deposition in the heart and both kidneys up to week 10, and restored the level of TBARS in the left ventricle and clipped kidney and the CAT activity in both kidneys until week 8. Ex without workload for 10 weeks in 2K1C rats provided distinct beneficial effects. The early effects of Ex on cardiovascular function included reversing MAP and reflex bradycardia. The later effects of Ex included preventing structural alterations in the heart and kidney by decreasing oxidative stress and reducing injuries in these organs during hypertension.
Sujet(s)
Animaux , Mâle , Hypertension rénovasculaire/physiopathologie , Rein/anatomopathologie , Myocarde/anatomopathologie , Stress oxydatif/physiologie , Conditionnement physique d'animal/physiologie , Pression artérielle/physiologie , Baroréflexe/physiologie , Bradycardie/métabolisme , Bradycardie/anatomopathologie , Catalase/métabolisme , Rythme cardiaque/physiologie , Rein/métabolisme , Myocarde/enzymologie , Myocarde/métabolisme , Artère rénale/chirurgie , Mode de vie sédentaire , Reconstructions chirurgicales , Facteurs temps , Substances réactives à l'acide thiobarbiturique/analyseRÉSUMÉ
The results of the schistosomiasis survey in Matag-ob and Villaba of Northwestern Leyte showed 78 school children out of the 385 examined to be positive for S. japonicum ova in their stools. Snail surveys revealed the presence of O. quadrasi which were naturally infected with S. japonicum cercariae. The endemicity of schistosomiasis japonica in these places is therefore established. Treatment of cases, intensive environmental sanitation and health education work are being carried out by the Provincial Health Office and Rural Health Units of these two Municipalities. (Author)