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Article Dans Anglais | IMSEAR | ID: sea-140101

Résumé

Context: Oxidative stress has been implicated in the pathogenesis of lichen planus, and a lower level of lycopene has been reported in erosive and atrophic oral lichen planus (OLP) patients. However, its efficacy in the management of OLP has not been reported. Aim: This study was designed to assess the efficacy of systemic lycopene in the management of OLP. Settings and Design: This prospective, randomized, double-blind, placebo-controlled study was done in the Oral Medicine Department of a postgraduate teaching dental hospital in India. Materials and Methods: Thirty symptomatic OLP patients, randomly divided into two groups of 15 each, were administered lycopene 8 mg/day and an identical placebo, respectively, for 8 consecutive weeks. Burning sensation using visual analogue scale and overall treatment response using Tel Aviv-San Francisco scale were recorded at every visit. The data obtained were analyzed statistically using Wilcoxon Rank test, Mann-Whitney and Fischer's Exact test. Results: A higher (84%) reduction in burning sensation was seen in lycopene than in the placebo group (67%). All 15 (100%) patients in the lycopene group showed 50% or more benefit and 11 (73.3%) patients showed 70-100% benefit, while this number was only 10 and 4 (26.7%), respectively, in the placebo group. Conclusion: Lycopene was very effective in the management of OLP, and oxidative stress may have a role in disease pathogenesis.


Sujets)
Adolescent , Adulte , Sujet âgé , Antioxydants/administration et posologie , Antioxydants/usage thérapeutique , Caroténoïdes/administration et posologie , Caroténoïdes/usage thérapeutique , Méthode en double aveugle , Femelle , Études de suivi , Humains , Lichen plan buccal/traitement médicamenteux , Mâle , Adulte d'âge moyen , Stress oxydatif/effets des médicaments et des substances chimiques , Mesure de la douleur , Placebo , Études prospectives , Induction de rémission , Résultat thérapeutique , Jeune adulte
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