Résumé
Sixty-seven diabetic patients and 12 normal subjects were selected for a clinical study with an indigenous herbal product. The study consisted of 2 phases. In phase 1 study out of 25 diabetics (both insulin dependent and non-insulin dependent) only those in the age group of 41-50 years ie, 11 cases showed lowering of mean high blood sugar level in all samples from 1/2 an-hour to 2 hours with the test drug containing guar gum, methi, tundika and mesha shringi. But in phase 2 study there was lowering of blood sugar level with the test drug and with 2 of its constituents ie, guar gum and methi when used separately in 42 non-insulin dependent diabetics. While there was some blood sugar level lowering effect with guar gum and methi when used separately in 12 normal subjects in phase 2 study, but that was not the same observed with the test drug. The results of this study indicate the efficacy of the product as an adjuvant.
Sujets)
Adulte , Glycémie/analyse , Diabète de type 1/sang , Diabète de type 2/sang , Femelle , Hyperglycémie provoquée , Humains , Mâle , Médecine ayurvédique , Adulte d'âge moyen , Plantes médicinales/physiologie , Facteurs tempsRésumé
Two cases with true hermaphroditism are described. A 2 year old child presented with ambiguous genitalia, and had bilateral ovotestis in the labioscrotal folds. A 20 year old boy presented with grade V gynaecomastia and periodical bleeding as well as seminal discharge after phallic stimulation; he had right sided ovotestis, normal size uterus, left ovary and hypoplastic fallopian tubes. Male gender was assigned to both. Cytogenetically both were 46XX. Gonadectomy was done in both the cases. Bilateral mastectomy and hysterectomy was done in the second case.
Sujets)
Adulte , Enfant d'âge préscolaire , Troubles du développement sexuel/diagnostic , Humains , Caryotypage , MâleSujets)
Animaux , Beurre , Caséines/isolement et purification , Bovins , Phénomènes chimiques , Chimie , Électrolytes , Femelle , Lipides , Lait , UréeSujets)
Animaux , Beurre , Caséines , Bovins , Détergents , Femelle , Liaison aux protéines , Relation structure-activité , TensioactifsRésumé
The study of thyroid function in clinical conditions associated with the disorders of the hypothalamio-pituitary-adrenocortical axis indicated overt hypofunction of thyroid in all the three cases of Cushing's disease and subclinical hypo-or low normal function of thyroid in most of the cases of adrenogenital syndrome. It was suggested that hypo or low normal function of thyroid might facilitate excess elaboration of ACTH through CRF by swaying the balance of neurotransmitters at hypothalamus in favour of serotonin.