Résumé
Objectives: To compare the efficacy and safety of Misoprostol for termination of pregnancy in second trimester in scarred versus unscarred uterus
Study Design: Quasi-experimental study
Setting: Obstetrics and Gynaecology unit of Allied / DHQ Hospitals affiliated with Punjab Medical College, Faisalabad
Subjects and Method: During 6 months period from 22nd March, 2007 to 22nd September, 2007. 60 patients [30 with scarred and 30 with unscarred uterus] were admitted for second trimester termination of pregnancy for maternal reason, fetal congenital anomalies and intrauterine fetal demise and induced with vaginal misoprostol. Loading dose of 400 mcg followed by maintenance dose of 200 mcg at 4 hourly interval to a maximum of 4 doses
Main Outcome Measures: Efficacy included induction to delivery interval and safety included maternal complications and side effects like uterine rupture, hysterectomy, severe haemorrhage, pyrexia, nausea and vomiting
Results: Success rate of T.O.P. was 96.7% in group A [scarred uterus] VS 93.3% in group B [unscarred uterus] Maternal complications were nausea and vomiting 3.3% in group A VS 0% in group B, Pyrexia 3.3% in each group, no case of uterine rupture was recorded
Conclusion: Misoprostol is safe and effective drug for Midtrimester T.O.P. in scarred as well as unscarred uterus