Psychosocial Correlates of Attempted Suicide and Attitudes Toward Suicide / 신경정신의학

OBJECTIVES: To examine psychosocial correlates of suicide attempts in a community population. METHODS: This study investigated suicide attempt history, demographic and psychosocial characteristics including depression using the Beck Depression Inventory (BDI), and responses to a questionnaire about attitudes toward suicide in a community sample. The demographic and psychosocial correlates of suicide attempts were evaluated using univariate and multivariate analyses. RESULTS: A total of 1,578 people completed the survey. Of these, 100 people (6.3%) had attempted suicide. In the univariate analyses, risk factors for attempted suicide were divorce, lower level of education, lack of a stable job, living in a rented house, undergoing psychiatric treatment, a family history of psychiatric illness, and being depressed (BDI > or =22). In the multivariate analysis, living in a rented house, undergoing psychiatric treatment, and being depressed were significantly associated with attempted suicide. Of the individuals who had attempted suicide, 42.0% were currently depressed, whereas the prevalence of depression in those who had not attempted suicide was 9.1%. In addition, individuals who had attempted suicide had permissive attitudes toward suicide and negative attitudes toward treatment for suicidal behavior. CONCLUSION: Attempted suicide was significantly associated with depression. Therefore, immediate and appropriate psychiatric treatment for depression in those attempting suicide is crucial.

Expression of Chemokine Receptors in Ovarian Cancer Tissue / 대한산부인과학회잡지

OBJECTIVE: We investigated the expression of chemokine receptors in human ovarian cancer to understand the role of chemokines in ovarian cancer development and metastasis. METHODS: Twenty-two cases of epithelial ovarian cancer were studied for expression of 13 chemokine receptors such as CXCR1-CXCR5 and CCR1-CCR8 by using semi- quantitative RT-PCR and immunohistochemistry. Moreover, we studied the relationship between the chemokine receptors expression and lymph nodes metastasis of ovarian cancers. RESULTS: As compared with normal ovarian tissues, ovarian cancer tissues showed higher mean expression levels of CCR1,3,4,5,7,8 and CXCR1,3,4. Of chemokine receptors, CCR7 revealed the significantly higher levels of expression in ovarian cancer tissues relative to normal tissues. In the cases of retroperitoneal lymph nodes metastasis, increased expression of CCR2,4 and CXCR 1,3,4 was observed although there was no statistical significance. CONCLUSION: These results suggest that there is a complex chemokine/chemokine receptor network in pathogenesis and the way of lymph node metastasis of ovarian cancer rather than a specific chemokine or chemokine receptor.