Résumé
In vitro effects of aspirin and paracetamol at the doses 200, 400, 600, 800 nmole/mg protein on ATPases activity were studied in the cerebrum and cerebellum of human fetus covering the age range from 10 weeks to 32 weeks of gestation. Both aspirin and paracetamol inhibit Na+K+ ATPase and Mg2+ ATPase in a dose dependent manner. The inhibition of Na+K+ ATPase and Mg2+ ATPase activity which may affect the release and uptake of biogenic amines in CNS, hinders the maturation of human fetal brain.
Sujets)
Acétaminophène/pharmacologie , Adenosine triphosphatases/métabolisme , Acide acétylsalicylique/pharmacologie , Ca(2+) Mg(2+)-ATPase/métabolisme , Femelle , Foetus/effets des médicaments et des substances chimiques , Humains , Grossesse , Sodium-Potassium-Exchanging ATPase/métabolismeRésumé
The in vitro effect of doxepin at 10, 50 and 200 micrograms/mg protein on Mg2+ and (Na+ K+)-ATPases (EC 3.6.1.3) activities of human foetal and adult brain (crude homogenate of cerebrum and cerebellum) were studied at 10-30 wk of gestation. Both Mg2+ and (Na+, K+)-ATPases of human foetal and adult brain were found to be inhibited by doxepin in a dose dependent manner. The inhibitory effect neither varied with respect to the region (i.e., cerebrum and cerebellum) nor with the gestational ages. Inhibition of ATPases activity by doxepin may affect the release and uptake of biogenic amines in the CNS, which may hamper the maturation of brain.
Sujets)
Adulte , Encéphale/effets des médicaments et des substances chimiques , Ca(2+) Mg(2+)-ATPase/métabolisme , Doxépine/pharmacologie , Foetus/effets des médicaments et des substances chimiques , Humains , Sodium-Potassium-Exchanging ATPase/métabolismeRésumé
Lorazepam (LZ), a benzodiazepine group of drug, inhibits Mg2+ and (Na+,K+) ATPases (EC 3.6.1.3) activity of human foetal and adult brain. The inhibitory effect neither varied with respect to the region (i.e. cerebrum and cerebellum) nor with the age of the foetus. The inhibition of ATPases activity indicates that the neuronal transmission processes, may be affected and raises the possibility of developmental disturbances.