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1.
Acta Academiae Medicinae Sinicae ; (6): 840-844, 2021.
Article Dans Chinois | WPRIM | ID: wpr-921547

Résumé

Gastrointestinal stromal tumors(GISTs)in the stomach,duodenum,and rectum have low occurrence,and the coexistence GISTs in three parts with neurofibromatosis type Ⅰ(NF-Ⅰ)is even rare.This paper reports a case of GISTs with a family history of NF-Ⅰ.There were multiple nodular masses of different sizes on the patient's face,trunk,and limbs.The patient was admitted due to chest tightness for 5 days and black stools for 1 day.Enhanced CT examination of the abdomen suggested multiple space-occupying lesions in the upper abdomen with multiple small nodules under the abdominal wall,and neurofibromatosis and intestinal stromal tumor cannot be excluded.Finally,surgical pathology confirmed that the multiple tumors in the abdominal cavity were GISTs.The case was confirmed as wild-type GISTs by genetic testing,and the patient recovered well nearly one year after the operation.


Sujets)
Humains , Tumeurs stromales gastro-intestinales/génétique , Neurofibromatose de type 1/génétique
2.
China Journal of Chinese Materia Medica ; (24): 828-832, 2015.
Article Dans Chinois | WPRIM | ID: wpr-330225

Résumé

In the fast pace of modern life and under the heavy work pressure, the prevalence of depression has increased year by year. Meanwhile, the demands for antidepressant drugs have also grown, especially the high-efficiency and low-toxicity natural antidepressant drugs, mainly including polyphenols, flavonoids, organic acids, alkaloids and terpenoids. Cytochrome P450 (CYP450) is a type of enzymes involving oxidative metabolism of drugs in vivo, and can change the pharmacokinetics and efficacy of drugs. Therefore, it is of important significant to define the effect of natural antidepressant drugs on CYP450 in human bodies, in order to improve the rational clinical medication, avoid drug interactions and reduce adverse reactions.


Sujets)
Animaux , Humains , Antidépresseurs , Pharmacologie , Inhibiteurs des enzymes du cytochrome P-450 , Pharmacologie , Cytochrome P-450 enzyme system , Métabolisme , Dépression , Traitement médicamenteux , Médicaments issus de plantes chinoises , Pharmacologie
3.
China Journal of Chinese Materia Medica ; (24): 3736-3741, 2013.
Article Dans Chinois | WPRIM | ID: wpr-291293

Résumé

To study the analgesic effect of chronic administration with ferulic acid, and preliminarily discuss its mechanism. Thermal hyperalgesia and mechanical allodynia tests were conducted to observe the analgesic effect of chronic administration with ferulic acid on CCI mice. The neurochemical detection method was applied to observe the effect chronic administration with ferulic acid on monoamine neurotransmitter and monoamine oxidase activity. Compared with the normal group, CCI mice showed notable reduction in heat sensation and nociceptive threshold in and mechanical allodynia. Ferulic acid (10, 20, 40 and 80 mg x kg(-1), po) could significantly reverse the situations. In an in-depth study, we found that the reason for these results was that ferulic acid was dose-dependent in increasing 5-HT and NE levels in hippocampus, frontal cortex and amygdale and could inhibit MAO-A activity in mouse brains. These results showed that ferulic acid has the analgesic effect. Its mechanism may be related to the inhibition of monoamine oxidase activity and the increase in monoamine neurotransmitter in mouse brains.


Sujets)
Animaux , Humains , Mâle , Souris , Analgésiques , Comportement animal , Acides coumariques , Hyperalgésie , Traitement médicamenteux , Psychologie , Souris de lignée ICR , Monoamine oxidase , Métabolisme , Agents neuromédiateurs , Métabolisme , Nerf ischiatique , Plaies et blessures , Neuropathie du nerf sciatique , Traitement médicamenteux , Métabolisme , Psychologie
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