Assessment of tolerability of beta- blockade therapy in patient with left ventricular systolic dysfunction heart failure

Little data exist to demonstrate the tolerability of beta-blocker therapy in an unselected community heart failure population already treated with the clinical trial or higher dose ACEI or ARB. 141 patients who had left ventricular systolic failure on standard therapy were recruited in our study. Patients were assigned to receive either Carvedilol or Bisoprolol. This prospective observational study showed that beta-blocker therapy is well tolerated and can be safely titrated in an out-patient setting