Motor-Blocking effects of ropivacaine and bupivacaine, in the animals [frog and rat]

The current study was designed to assess the motor effect of ropivacaine and bupivacaine in vitro by using isolated frog rectus abdominis muscle and in vivo by using sciatic nerve blockade in the rat. In vitro experiments showed that ropivacaine and bupivacaine in the same equivalent doses [3-48 mug/ml] produced dose-dependent reduction in the acetylcholine induced contractions of isolated frog rectus abdominis muscle. The results have demonstrated that the depressant effect of bupivacaine was greater than that of ropivacaine on motor activity. However, ropivacaine had significantly shorter time of onset with shorter duration of motor block

Comparative study of the haemodynamic effects of sevoflurane and halothane in children

This study was designed to compare between halothane and sevoflurane in pediatric patients regards hemodynamic response to inhalational induction. The study was carried out on 40 patients [ASA physical status I or II] scheduled for elective surgery and divided into 2 groups, each 20 patients. The results showed that sevoflurane is as safe as halothane for rapid inhalational induction in children. Also, sevoflurane provided hemodynamic stability during induction with maintenance of blood pressure, mildly increasing heart rate and lack of arrhythmogenicity