Résumé
The aim of the present work was to formulate ciprofloxacin HCl sponges for the management of wounds. Fifteen plain sponge formulae were prepared, using mixtures of chitosan/sodium alginate [C/SA], chitosan/gelatin [C/G] and sodium alginate/gelatin [SA/G] by the freeze drying method. The resulted plain sponges were evaluated for their visual inspection, mechanical properties as well as their swelling properties. Plain sponge formulae were selected as they were superior in the physical properties. Ciprofloxacin HCl [1%W/V] was thus incorporated into them. The prepared medicated sponges were thoroughly evaluated for the physical properties. Detection of any possible interaction between the mixtures of polymers and ciprofloxacin HCl by IR, DSC and SEM and drug release was done. Analysis by IR and DSC did not show any drug/ polymers interaction. Ciprofloxacin sponges prepared with chiosan 1% and gelatin 1% [1:1], 5% calcium chloride as a cross linking agent and ciprofloxacin HCl 1% showed the highest prolonged release formula. Trials were done on an animal model for evaluation of wound healing efficiency. Ciprofloxacin sponges showed faster wound healing properties compared to in comparison with Gentamicin cream