Résumé
To find out whether the combination regimen of mefloquine and artesunate tablets improves the cure rate in uncomplicated falciparum malaria compared to the use of mefloquine and artesunate as single agents, a prospective, randomised, uniblind controlled study was done between May and November 1991, on one hundred and eighty cases of acute uncomplicated falciparum malaria. The patients were randomised to the following three frug regimens: - (1) Mefloquine - 1000 mg stat, (2) Tab Artesunate 600 mg over 48 hours, (3) Mefloquine 1000 mg plus tab Artesunate 600 mg over 48 hours. The regimen of mefloquine as a single agent gave a cure rate of 83.3 percent (with R1 = 15 percent and R2 = 1.7 percent), PCT = 52.15 + 55.2 hours and FCT = 23.98 + 59.87 hours. Tab artesunate gave a cure rate of 75 percent (with R1 = 25 percent), PCT = 33.16 + 5.15 and FCT = 23.4 + 22.7 hours. The combination regimen gave a cure rate of 98.27 percent with only one patient recrudescing at R1 level, PCT = 35.11 + 29.16 and FCT = 8.15 + 10.34 hours. The side effects were not much increased by using the combination. No cardiovascular effects were noted. The combination is superior to that of the single agents.
Sujets)
MéfloquineRésumé
Differential study of the maker enzyme level for intracellular organelles in intestinal mucosa and muscularis layer following E. coli labile toxin (LT) administration to rat revealed that there were no changes in the enzyme levels in mucosa but some changes (a degree of acid phophatase and an increase of proteinase) in muscularis layer. The results suggest that the LT, being a high molecular weight toxin, may not be easily invaginated into intestinal epithelial cells and interact with the subcellular particles. The changes in the enzyme activities observed in the muscularis layer could be the abnormal metabolic consequences of prolonged hypersecretion produced by LT.