Histopathological Features of H.pyloriinduced Gastritis and Improvement of Gastritis after Eradication of H.pylori / 대한내과학회지

OBJECTIVES: This study was designed to investigate the distribution of Helicobacter pylori(HP), the relationship between HP colonization and gastritis scores graded according to the Sydney system, epithelial damage, and lymphoid follicles, and to assess the effect of eradication of HP infection on the different histological parameters. METHODS: Gastritis scores, epithelial damage, and lymphoid follicles were assessed in gastric antral, body, and fundic biopsy specimens before and 4 weeks after antiHP triple therapy in 32 patients with HP-related gastritis. RESULTS: The mean initial scores of all histological parameters were higher in the antrum compared with the body and fundus. A significant, positive correlation was noted between HP score and the score for inflammation, for activity, and for mucus depletion. After eradication of HP infection, significant improvement in activity, chronic inflammation, and mucus depletion was detected in responders with a successful HP eradication ; the activity return to normal in follow-up, and chronic inflammation and mucus depletion was decreased significally in severity in responders(p<0.05). No significant reduction in severity of gastritis and mucus depletion was detected in the non-responders with persistent HP infection following anti-HP triple therapy. CONCLUSIONS: The eradication of HP results in a rapid, significant histopathological improvement in the gastritis scores and epithelial damage in gastric mucosa.

Gastric Histopathology and Serum Levels of Gastric Peptides according to Types of Helicobacter Pylori in Patients with Functional Dyspepsia / 대한소화기내시경학회지

BACKGROUND/AIMS: Clinical isolates of Helicobacter pylori (H. pylori) can be divided into at least two major types. Type I bacteria express VacA (vacuolating cytotoxin) and CagA (cytotoxin-associated antigen), type II bacteria do not exp~ress VacA or CagA. The purpose of this study is to evaluate the changes of gastric histology and serum level of gastric peptides (gastrin and pepsinogen) according to the bacteriological types in H. pylori infection. METHODS: In patients with H. pylori-positive functional dyspepsia, we classified the type of infection serologically by detecting IgG antibodies to CagA and VacA. Each patient was also evaluated for the degree of gastric inflammation and serum concentrations of gastrin and pepsinogen (PG). IgG antibodies to these proteins and concentrations of gastrin and PG were detected by using a immuno-blot kit and a radioimmunoassay kit, respectively, from the sera of each patient. From endoscopically biopsied antral specimens, the degree of gastric inflammation was evaluated by scoring inflammatory changes.

Abdominal Pregnancy in the Liver: A Case Report / 대한산부인과학회잡지

Abdominal pregnancies are rare forms of ectopic pregnancies. Although the pelviccavity is the preferential site, a small fraction of abdominal pregnancies has been found inthe upper abdominal cavity, e.g., the omentum, the spleen, the liver etc. In this manuscript,we first report a Korean case of hepatic pregnancy which was highly suggested by operativefindings. A 24-year-old woman underwent laparotomy under the impression ofhemoperitoneum and ectopic pregnancy. An 1 x 1x 0.5cm sized mass was removed from thesurface of the right lobe of the liver. Microscopically, the chorionic villi were demonstrated.The patient had a successful recovery.

A Case of Xanthogranulomatous Pyelonephritis Associated with Xanthogranulomatous Epididymoorchitis

Xanthogranulomatous pyelonephritis is an atypical severe renal parenchymal infection, characterized macroscopically by a yellow lobulated mass, and microscopically by massive inflammatory cells and foamyhystiocytes. Preoperatively it can be confused with hypernephroma, pyonephrosis with stone or other renal inflammatory diseases, We present a case of xanthogranulomatous pyelonephritis associated with xanthogranulomatous epididymoorchitis. To our knowledge this is the first report of xanthogranulomatous pyelonephritis associated with xanthogranulomatous epididymo-orchitis.

Massive Ovarian Edema: US and MRI Findings 3 Cases Report

Massive ovarian edema is a rare tumor-like condition occurring in young women; it involves enlargement of the ovary, caused by intermittent torsion of the mesovarium. Ultrasonographically, a well-defined inhomogeneous soft tissue mass lesion is seen, and this cannot be distinguished from other solid ovarian tumors. The MRI findings, seen on T1WI, are inhomogeneous high signal intensity of the central part, with peripheral low signal intensity of the mass lesion. On T2WI, the inner part of the mass shows high signal intensity and the peripheral part, low signal intensity. Ovarian follicles are arranged peripherally, and are seen as low signal intensity on T1WI, and high signal intensity on T2WI. These MR findings are specific for the diagnosis of massive ovarian edema.

Pulmonary Cavernous Hemangioma: A case report

The pulmonary cavernous hemangioma is usually from birth and there may be without symptoms until adulthood. Larger or multiple pulmonary angiomata with considerable pulmonary arteriovenous shunts may cause cyanosis, finger clubbing, dyspnea and frequently accompanyingbruit. Recently, we experienced a case of cavernous hemangioma of the lung. A 34-year-old woman was admitted to our hospital for surgical evaluation of a 4 cm solitary, round nodule in the right upper lobe on the chest X-ray and CT scan. She had no symptoms. Laboratory findings are within normal limits except for elevated glucose levels. At surgery, the mass was well encapsulated and easily excised from the peripheral portion of the posterior segment of the right upper lobe. Grossly, it consisted of a 4 cm in diameter, round, soft, sponge-like, hemorrhagic, slightly lobulated mass with a smooth external surface. Microscopically, the mass was composed of vessels, which were thin walled, dilated and filled with blood. The wall of the abnormal vessels was thin and composed of endothelium and fibrous connective tissue with only a little smooth muscle. Immunohistochemically, the wall of the dilated abnormal vessesls showed negative reaction for cytokeratin(low and high) and epithelial membrane antigen but weakly positive reaction for UEA-1 in focal areas.

Macrophage/dendritic Cell Marker Staining Characteristics of Langerhans cell Granulomatosis(Histiocytosis X)

Histiocytosis X is characterized by aggregates of Langerhans cells with other inflammatory cells. These Langerhans cells are antigen-presenting cells to T lymphocytes and identified by characteristic morphology, ultrastructural demonstration of Birbeck granules and immunologic reactivity with OKT-6 and HLA-DR antibodies. In this report, the tumor arising in a 2-years-old baby was examined byimmunostaining with several macrophage/dendritic cell markers. The main tumor cells showed cytoplasmic and nuclear staining with S-100 protein and ring-like surface and paranuclear staining with PNA. However, they were negative for follicular dendritic cell marker CD21, macrophage markers lysozyme, Mac 387, alpha-1 antitrypsin and CD68, and interdigitating reticulum cell marker ID4 and ID5. These observations demonstrate the usefulness of S-100 protein and PNA for the identification of Langerhans cells in paraffin-embedded tissue.

Eosinophilic Granuloma of the Lung

Eosinophilic granuloma of the lung, first described by Farrinaci et al. in 1951, is rare. A 35-year-old male smoker presented with recurrent pneumothorax. Open thoracotomy with bleb resection and biopsy was performed. Microscopically there was histological changes consistent with typical eosinophilic granuloma and intertitial fibrosis. The Langerhans cells showed positive reaction for S-100 protein and typical Birbeck granules in their cytoplasm. A brief summary of histopathological aspect of this disease and a review of literature are presented.

Collision carcinoma in a metastatic neck node / 대한이비인후과학회지

No abstract available.

Arteriovenous malformation of the uterus-a cause of massive operative bleeding

Arteriovenous malformations of the uterus are extremely rare and they occur either in congenital or acquired forms. The most common clinical presentation is abnormal uterine bleeding, which may be aggravated by therapeutic curettage. Because of their rare incidence and clinical importance in management of patients, we report a case of arteriovenous malformation causing serious bleeding during a hysterectomy for uterine leiomyoma. The patient was a 47-year-old multiparous woman who had a history of chronic vaginal bleeding for one year. Numerous anomalous blood vessels draining into the right and left uterine arteries were found on the anterior wall of the uterus and parametrium.