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1.
Korean Journal of Medicine ; : S253-S257, 2011.
Article Dans Coréen | WPRIM | ID: wpr-152518

Résumé

Thienopyridines are antiplatelet agents used in post-percutaneous coronary angioplasty patients and patients with acute coronary syndrome, stroke, and peripheral arterial disease. Ticlopidine has been shown to reduce the incidence of stent thrombosis, but it may also cause serious hematological side effects. Among the thienopyridines, clopidogrel is considered to be a safe alternative to ticlopidine because of its decreased incidence of hematological adverse effects. However, some hematological side effects can occur and may be fatal. In this case, a 47-year-old man complained of dyspnea and generalized edema. He had been taking clopidogrel after coronary angioplasty. His laboratory findings showed acute renal failure, microangiopathic hemolytic anemia, and thrombocytopenia, which were consistent with hemolytic uremic syndrome (HUS). After discontinuing clopidogrel and undergoing plasma exchange, he recovered fully. To our knowledge, this is the first reported case of clopidogrel-induced HUS in Korea.


Sujets)
Humains , Adulte d'âge moyen , Syndrome coronarien aigu , Atteinte rénale aigüe , Anémie hémolytique , Angioplastie , Dyspnée , Oedème , Syndrome hémolytique et urémique , Incidence , Corée , Maladie artérielle périphérique , Échange plasmatique , Antiagrégants plaquettaires , Endoprothèses , Accident vasculaire cérébral , Thiénopyridines , Thrombopénie , Thrombose , Ticlopidine
2.
Korean Journal of Medicine ; : 212-215, 2011.
Article Dans Coréen | WPRIM | ID: wpr-47591

Résumé

A 37-year-old woman presented to our hospital with a 1-month history of fever. She also complained of lower leg pain. Transthoracic echocardiography showed large vegetations on the mitral valve leaflets. Staphylococcus lugdunensis was isolated from blood cultures. She was diagnosed with infectious endocarditis due to S. lugdunensis and was treated with antibiotics and surgery. Infective endocarditis caused by S. lugdunensis can be invasive and often resembles endocarditis due to Staphylococcus aureus. Thus, whenever this organism is found in patients with endocarditis, early surgical treatment of the infected valve should be considered.


Sujets)
Adulte , Femelle , Humains , Antibactériens , Échocardiographie , Endocardite , Fièvre , Jambe , Valve atrioventriculaire gauche , Staphylococcus , Staphylococcus aureus , Staphylococcus lugdunensis
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